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PubMed:29146903 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells.
T1 0-102 Sentence denotes Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells.
T2 103-217 Sentence denotes Dysregulation of autophagy and inflammasome activity contributes to the development of auto-inflammatory diseases.
T2 103-217 Sentence denotes Dysregulation of autophagy and inflammasome activity contributes to the development of auto-inflammatory diseases.
T3 218-325 Sentence denotes Emerging evidence highlights the importance of the actin cytoskeleton in modulating inflammatory responses.
T3 218-325 Sentence denotes Emerging evidence highlights the importance of the actin cytoskeleton in modulating inflammatory responses.
T4 326-486 Sentence denotes Here we show that deficiency of Wiskott-Aldrich syndrome protein (WASp), which signals to the actin cytoskeleton, modulates autophagy and inflammasome function.
T4 326-486 Sentence denotes Here we show that deficiency of Wiskott-Aldrich syndrome protein (WASp), which signals to the actin cytoskeleton, modulates autophagy and inflammasome function.
T5 487-695 Sentence denotes In a model of sterile inflammation utilizing TLR4 ligation followed by ATP or nigericin treatment, inflammasome activation is enhanced in monocytes from WAS patients and in WAS-knockout mouse dendritic cells.
T5 487-695 Sentence denotes In a model of sterile inflammation utilizing TLR4 ligation followed by ATP or nigericin treatment, inflammasome activation is enhanced in monocytes from WAS patients and in WAS-knockout mouse dendritic cells.
T6 696-1050 Sentence denotes In ex vivo models of enteropathogenic Escherichia coli and Shigella flexneri infection, WASp deficiency causes defective bacterial clearance, excessive inflammasome activation and host cell death that are associated with dysregulated septin cage-like formation, impaired autophagic p62/LC3 recruitment and defective formation of canonical autophagosomes.
T6 696-1050 Sentence denotes In ex vivo models of enteropathogenic Escherichia coli and Shigella flexneri infection, WASp deficiency causes defective bacterial clearance, excessive inflammasome activation and host cell death that are associated with dysregulated septin cage-like formation, impaired autophagic p62/LC3 recruitment and defective formation of canonical autophagosomes.
T7 1051-1263 Sentence denotes Taken together, we propose that dysregulation of autophagy and inflammasome activities contribute to the autoinflammatory manifestations of WAS, thereby identifying potential targets for therapeutic intervention.
T7 1051-1263 Sentence denotes Taken together, we propose that dysregulation of autophagy and inflammasome activities contribute to the autoinflammatory manifestations of WAS, thereby identifying potential targets for therapeutic intervention.