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PubMed:29127443 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T1 0-105 Sentence denotes Astragaloside IV attenuates orbital inflammation in Graves' orbitopathy through suppression of autophagy.
T1 0-105 Sentence denotes Astragaloside IV attenuates orbital inflammation in Graves' orbitopathy through suppression of autophagy.
T2 106-119 Sentence denotes INTRODUCTION:
T2 106-119 Sentence denotes INTRODUCTION:
T3 120-219 Sentence denotes Graves' orbitopathy (GO) is an autoimmune inflammatory disorder affecting the orbit around the eye.
T3 120-219 Sentence denotes Graves' orbitopathy (GO) is an autoimmune inflammatory disorder affecting the orbit around the eye.
T4 220-342 Sentence denotes Astragaloside IV (AS-VI) is the main active ingredient of the Chinese herbal medicine Huangqi (Radix Astragali Mongolici).
T4 220-342 Sentence denotes Astragaloside IV (AS-VI) is the main active ingredient of the Chinese herbal medicine Huangqi (Radix Astragali Mongolici).
T5 343-549 Sentence denotes AS-IV exhibits antioxidant and anti-inflammatory properties, and shows therapeutic potential in a number of ischemic and inflammatory diseases; however, its pharmaceutical activities in GO remain undefined.
T5 343-549 Sentence denotes AS-IV exhibits antioxidant and anti-inflammatory properties, and shows therapeutic potential in a number of ischemic and inflammatory diseases; however, its pharmaceutical activities in GO remain undefined.
T6 550-572 Sentence denotes MATERIALS AND METHODS:
T6 550-572 Sentence denotes MATERIALS AND METHODS:
T7 573-838 Sentence denotes In this study, we investigated the effects of AS-IV on interleukin (IL)-1β-induced orbital fibroblast inflammation in vitro and GO orbital inflammation and ocular histopathological changes in vivo, as well as the underlying mechanisms responsible for these effects.
T7 573-838 Sentence denotes In this study, we investigated the effects of AS-IV on interleukin (IL)-1β-induced orbital fibroblast inflammation in vitro and GO orbital inflammation and ocular histopathological changes in vivo, as well as the underlying mechanisms responsible for these effects.
T8 839-862 Sentence denotes RESULTS AND CONCLUSION:
T8 839-862 Sentence denotes RESULTS AND CONCLUSION:
T9 863-1008 Sentence denotes The results show that IL-1β increased mRNA expression of the inflammatory cytokines IL-6, IL-8, TNF-α, and MCP-1 in cultured orbital fibroblasts.
T9 863-1008 Sentence denotes The results show that IL-1β increased mRNA expression of the inflammatory cytokines IL-6, IL-8, TNF-α, and MCP-1 in cultured orbital fibroblasts.
T10 1009-1185 Sentence denotes This IL-1β-induced inflammation was accompanied by increased autophagic activity as reflected in increased Beclin-1 and Agt-5 expression, as well as LC3-I to LC3-II conversion.
T10 1009-1185 Sentence denotes This IL-1β-induced inflammation was accompanied by increased autophagic activity as reflected in increased Beclin-1 and Agt-5 expression, as well as LC3-I to LC3-II conversion.
T11 1186-1457 Sentence denotes Pretreatment with the autophagy inhibitors 3-MA and bafilomycin A1, or silencing of autophagy-related proteins Beclin-1 and Atg-5, prevented IL-1β-induced orbital fibroblast inflammation, while pretreatment with the autophagy activator rapamycin had the opposite effects.
T11 1186-1457 Sentence denotes Pretreatment with the autophagy inhibitors 3-MA and bafilomycin A1, or silencing of autophagy-related proteins Beclin-1 and Atg-5, prevented IL-1β-induced orbital fibroblast inflammation, while pretreatment with the autophagy activator rapamycin had the opposite effects.
T12 1458-1534 Sentence denotes These data suggested that autophagy was involved in GO orbital inflammation.
T12 1458-1534 Sentence denotes These data suggested that autophagy was involved in GO orbital inflammation.
T13 1535-1769 Sentence denotes AS-IV treatment significantly decreased IL-1β-induced inflammatory cytokine production in orbital fibroblasts in vitro and attenuated GO orbital inflammation, fat accumulation, collagen deposition, and macrophage infiltration in vivo.
T13 1535-1769 Sentence denotes AS-IV treatment significantly decreased IL-1β-induced inflammatory cytokine production in orbital fibroblasts in vitro and attenuated GO orbital inflammation, fat accumulation, collagen deposition, and macrophage infiltration in vivo.
T14 1770-1948 Sentence denotes These in vitro and in vivo protective effects of AS-IV against GO were accompanied by decreased autophagic activities in orbital fibroblasts and GO orbital tissues, respectively.
T14 1770-1948 Sentence denotes These in vitro and in vivo protective effects of AS-IV against GO were accompanied by decreased autophagic activities in orbital fibroblasts and GO orbital tissues, respectively.
T15 1949-2050 Sentence denotes Collectively, our findings suggested that AS-IV protects against GO through suppression of autophagy.
T15 1949-2050 Sentence denotes Collectively, our findings suggested that AS-IV protects against GO through suppression of autophagy.
T16 2051-2099 Sentence denotes Thus, AS-IV may have preventive benefits for GO.
T16 2051-2099 Sentence denotes Thus, AS-IV may have preventive benefits for GO.