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PubMed:29099398 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Electric Field Based Dressing Disrupts Mixed-Species Bacterial Biofilm Infection and Restores Functional Wound Healing.
T1 0-119 Sentence denotes Electric Field Based Dressing Disrupts Mixed-Species Bacterial Biofilm Infection and Restores Functional Wound Healing.
T2 120-130 Sentence denotes OBJECTIVE:
T2 120-130 Sentence denotes OBJECTIVE:
T3 131-278 Sentence denotes This study was designed to employ electroceutical principles, as an alternative to pharmacological intervention, to manage wound biofilm infection.
T3 131-278 Sentence denotes This study was designed to employ electroceutical principles, as an alternative to pharmacological intervention, to manage wound biofilm infection.
T4 279-573 Sentence denotes Mechanism of action of a United States Food and Drug Administration-cleared wireless electroceutical dressing (WED) was tested in an established porcine chronic wound polymicrobial biofilm infection model involving inoculation with Pseudomonas aeruginosa PAO1 and Acinetobacter baumannii 19606.
T4 279-573 Sentence denotes Mechanism of action of a United States Food and Drug Administration-cleared wireless electroceutical dressing (WED) was tested in an established porcine chronic wound polymicrobial biofilm infection model involving inoculation with Pseudomonas aeruginosa PAO1 and Acinetobacter baumannii 19606.
T5 574-585 Sentence denotes BACKGROUND:
T5 574-585 Sentence denotes BACKGROUND:
T6 586-642 Sentence denotes Bacterial biofilms represent a major wound complication.
T6 586-642 Sentence denotes Bacterial biofilms represent a major wound complication.
T7 643-745 Sentence denotes Resistance of biofilm toward pharmacologic interventions calls for alternative therapeutic strategies.
T7 643-745 Sentence denotes Resistance of biofilm toward pharmacologic interventions calls for alternative therapeutic strategies.
T8 746-794 Sentence denotes Weak electric field has anti-biofilm properties.
T8 746-794 Sentence denotes Weak electric field has anti-biofilm properties.
T9 795-900 Sentence denotes We have previously reported the development of WED involving patterned deposition of Ag and Zn on fabric.
T9 795-900 Sentence denotes We have previously reported the development of WED involving patterned deposition of Ag and Zn on fabric.
T10 901-1036 Sentence denotes When moistened, WED generates a weak electric field without any external power supply and can be used as any other disposable dressing.
T10 901-1036 Sentence denotes When moistened, WED generates a weak electric field without any external power supply and can be used as any other disposable dressing.
T11 1037-1154 Sentence denotes METHODS: WED dressing was applied within 2 hours of wound infection to test its ability to prevent biofilm formation.
T11 1037-1154 Sentence denotes METHODS: WED dressing was applied within 2 hours of wound infection to test its ability to prevent biofilm formation.
T12 1155-1255 Sentence denotes Alternatively, WED was applied after 7 days of infection to study disruption of established biofilm.
T12 1155-1255 Sentence denotes Alternatively, WED was applied after 7 days of infection to study disruption of established biofilm.
T13 1256-1330 Sentence denotes Wounds were treated with placebo dressing or WED twice a week for 56 days.
T13 1256-1330 Sentence denotes Wounds were treated with placebo dressing or WED twice a week for 56 days.
T14 1331-1339 Sentence denotes RESULTS:
T14 1331-1339 Sentence denotes RESULTS:
T15 1340-1440 Sentence denotes Scanning electron microscopy demonstrated that WED prevented and disrupted wound biofilm aggregates.
T15 1340-1440 Sentence denotes Scanning electron microscopy demonstrated that WED prevented and disrupted wound biofilm aggregates.
T16 1441-1517 Sentence denotes WED accelerated functional wound closure by restoring skin barrier function.
T16 1441-1517 Sentence denotes WED accelerated functional wound closure by restoring skin barrier function.
T17 1518-1669 Sentence denotes WED blunted biofilm-induced expression of (1) P. aeruginosa quorum sensing mvfR (pqsR), rhlR and lasR genes, and (2) miR-9 and silencing of E-cadherin.
T17 1518-1669 Sentence denotes WED blunted biofilm-induced expression of (1) P. aeruginosa quorum sensing mvfR (pqsR), rhlR and lasR genes, and (2) miR-9 and silencing of E-cadherin.
T18 1670-1730 Sentence denotes E-cadherin is critically required for skin barrier function.
T18 1670-1730 Sentence denotes E-cadherin is critically required for skin barrier function.
T19 1731-1893 Sentence denotes Furthermore, WED rescued against biofilm-induced persistent inflammation by circumventing nuclear factor kappa B activation and its downstream cytokine responses.
T19 1731-1893 Sentence denotes Furthermore, WED rescued against biofilm-induced persistent inflammation by circumventing nuclear factor kappa B activation and its downstream cytokine responses.
T20 1894-1905 Sentence denotes CONCLUSION:
T20 1894-1905 Sentence denotes CONCLUSION:
T21 1906-2080 Sentence denotes This is the first pre-clinical porcine mechanistic study to recognize the potential of electroceuticals as an effective platform technology to combat wound biofilm infection.
T21 1906-2080 Sentence denotes This is the first pre-clinical porcine mechanistic study to recognize the potential of electroceuticals as an effective platform technology to combat wound biofilm infection.