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PubMed:29045486 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes.
T1 0-124 Sentence denotes Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes.
T2 125-270 Sentence denotes Thiamine is an essential enzyme cofactor required for proper metabolic function and maintenance of metabolism and energy production in the brain.
T2 125-270 Sentence denotes Thiamine is an essential enzyme cofactor required for proper metabolic function and maintenance of metabolism and energy production in the brain.
T3 271-477 Sentence denotes In developed countries, thiamine deficiency (TD) is most often manifested following chronic alcohol consumption leading to impaired mitochondrial function, oxidative stress, inflammation and excitotoxicity.
T3 271-477 Sentence denotes In developed countries, thiamine deficiency (TD) is most often manifested following chronic alcohol consumption leading to impaired mitochondrial function, oxidative stress, inflammation and excitotoxicity.
T4 478-566 Sentence denotes These biochemical lesions result in apoptotic cell death in both neurons and astrocytes.
T4 478-566 Sentence denotes These biochemical lesions result in apoptotic cell death in both neurons and astrocytes.
T5 567-773 Sentence denotes Comparable histological injuries in patients with hypoxia/ischemia and TD have been described in the thalamus and mammillary bodies, suggesting a congruency between the cellular responses to these stresses.
T5 567-773 Sentence denotes Comparable histological injuries in patients with hypoxia/ischemia and TD have been described in the thalamus and mammillary bodies, suggesting a congruency between the cellular responses to these stresses.
T6 774-907 Sentence denotes Consistent with hypoxia/ischemia, TD stabilizes and activates Hypoxia Inducible Factor-1α (HIF-1α) under physiological oxygen levels.
T6 774-907 Sentence denotes Consistent with hypoxia/ischemia, TD stabilizes and activates Hypoxia Inducible Factor-1α (HIF-1α) under physiological oxygen levels.
T7 908-991 Sentence denotes However, the role of TD-induced HIF-1α in neurological injury is currently unknown.
T7 908-991 Sentence denotes However, the role of TD-induced HIF-1α in neurological injury is currently unknown.
T8 992-1128 Sentence denotes Using Western blot analysis and RT-PCR, we have demonstrated that TD induces HIF-1α expression and activity in primary mouse astrocytes.
T8 992-1128 Sentence denotes Using Western blot analysis and RT-PCR, we have demonstrated that TD induces HIF-1α expression and activity in primary mouse astrocytes.
T9 1129-1296 Sentence denotes We observed a time-dependent increase in mRNA and protein expression of the pro-apoptotic and pro-inflammatory HIF-1α target genes MCP1, BNIP3, Nix and Noxa during TD.
T9 1129-1296 Sentence denotes We observed a time-dependent increase in mRNA and protein expression of the pro-apoptotic and pro-inflammatory HIF-1α target genes MCP1, BNIP3, Nix and Noxa during TD.
T10 1297-1417 Sentence denotes We also observed apoptotic cell death in TD as demonstrated by PI/Annexin V staining, TUNEL assay, and Cell Death ELISA.
T10 1297-1417 Sentence denotes We also observed apoptotic cell death in TD as demonstrated by PI/Annexin V staining, TUNEL assay, and Cell Death ELISA.
T11 1418-1589 Sentence denotes Pharmacological inhibition of HIF-1α activity using YC1 and thiamine repletion both reduced expression of pro-apoptotic HIF-1α target genes and apoptotic cell death in TD.
T11 1418-1589 Sentence denotes Pharmacological inhibition of HIF-1α activity using YC1 and thiamine repletion both reduced expression of pro-apoptotic HIF-1α target genes and apoptotic cell death in TD.
T12 1590-1783 Sentence denotes These results demonstrate that induction of HIF-1α mediated transcriptional up-regulation of pro-apoptotic/inflammatory signaling contributes to astrocyte cell death during thiamine deficiency.
T12 1590-1783 Sentence denotes These results demonstrate that induction of HIF-1α mediated transcriptional up-regulation of pro-apoptotic/inflammatory signaling contributes to astrocyte cell death during thiamine deficiency.