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PubMed:28512217 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish.
T1 0-99 Sentence denotes Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish.
T2 100-208 Sentence denotes RAD51 is an indispensable homologous recombination protein, necessary for strand invasion and crossing over.
T2 100-208 Sentence denotes RAD51 is an indispensable homologous recombination protein, necessary for strand invasion and crossing over.
T3 209-349 Sentence denotes It has recently been designated as a Fanconi anemia (FA) gene, following the discovery of two patients carrying dominant-negative mutations.
T3 209-349 Sentence denotes It has recently been designated as a Fanconi anemia (FA) gene, following the discovery of two patients carrying dominant-negative mutations.
T4 350-499 Sentence denotes FA is a hereditary DNA-repair disorder characterized by various congenital abnormalities, progressive bone marrow failure, and cancer predisposition.
T4 350-499 Sentence denotes FA is a hereditary DNA-repair disorder characterized by various congenital abnormalities, progressive bone marrow failure, and cancer predisposition.
T5 500-568 Sentence denotes In this report, we describe a viable vertebrate model of RAD51 loss.
T5 500-568 Sentence denotes In this report, we describe a viable vertebrate model of RAD51 loss.
T6 569-734 Sentence denotes Zebrafish rad51 loss-of-function mutants developed key features of FA, including hypocellular kidney marrow, sensitivity to cross-linking agents, and decreased size.
T6 569-734 Sentence denotes Zebrafish rad51 loss-of-function mutants developed key features of FA, including hypocellular kidney marrow, sensitivity to cross-linking agents, and decreased size.
T7 735-887 Sentence denotes We show that some of these symptoms stem from both decreased proliferation and increased apoptosis of embryonic hematopoietic stem and progenitor cells.
T7 735-887 Sentence denotes We show that some of these symptoms stem from both decreased proliferation and increased apoptosis of embryonic hematopoietic stem and progenitor cells.
T8 888-1008 Sentence denotes Comutation of p53 was able to rescue the hematopoietic defects seen in the single mutants, but led to tumor development.
T8 888-1008 Sentence denotes Comutation of p53 was able to rescue the hematopoietic defects seen in the single mutants, but led to tumor development.
T9 1009-1176 Sentence denotes We further demonstrate that prolonged inflammatory stress can exacerbate the hematological impairment, leading to an additional decrease in kidney marrow cell numbers.
T9 1009-1176 Sentence denotes We further demonstrate that prolonged inflammatory stress can exacerbate the hematological impairment, leading to an additional decrease in kidney marrow cell numbers.
T10 1177-1395 Sentence denotes These findings strengthen the assignment of RAD51 as a Fanconi gene and provide more evidence for the notion that aberrant p53 signaling during embryogenesis leads to the hematological defects seen later in life in FA.
T10 1177-1395 Sentence denotes These findings strengthen the assignment of RAD51 as a Fanconi gene and provide more evidence for the notion that aberrant p53 signaling during embryogenesis leads to the hematological defects seen later in life in FA.
T11 1396-1559 Sentence denotes Further research on this zebrafish FA model will lead to a deeper understanding of the molecular basis of bone marrow failure in FA and the cellular role of RAD51.
T11 1396-1559 Sentence denotes Further research on this zebrafish FA model will lead to a deeper understanding of the molecular basis of bone marrow failure in FA and the cellular role of RAD51.