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PubMed:28511649 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes IL-10 ameliorates TNF-α induced meniscus degeneration in mature meniscal tissue in vitro.
T1 0-89 Sentence denotes IL-10 ameliorates TNF-α induced meniscus degeneration in mature meniscal tissue in vitro.
T2 90-101 Sentence denotes BACKGROUND:
T2 90-101 Sentence denotes BACKGROUND:
T3 102-282 Sentence denotes Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death.
T3 102-282 Sentence denotes Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death.
T4 283-447 Sentence denotes The aim of this study was to examine whether anti-inflammatory interleukin-10 exerts protective effects in an in vitro model of TNF-α-induced meniscus degeneration.
T4 283-447 Sentence denotes The aim of this study was to examine whether anti-inflammatory interleukin-10 exerts protective effects in an in vitro model of TNF-α-induced meniscus degeneration.
T5 448-456 Sentence denotes METHODS:
T5 448-456 Sentence denotes METHODS:
T6 457-516 Sentence denotes Meniscus tissue was harvested from the knees of adult cows.
T6 457-516 Sentence denotes Meniscus tissue was harvested from the knees of adult cows.
T7 517-608 Sentence denotes After 24 h of equilibrium explants were simultaneously treated with bovine TNF-α and IL-10.
T7 517-608 Sentence denotes After 24 h of equilibrium explants were simultaneously treated with bovine TNF-α and IL-10.
T8 609-815 Sentence denotes After an incubation time of 72 h cell death was measured histomorphometrically (nuclear blebbing, NB) and release of glycosaminoglycans (GAG, DMMB assay) and nitric oxide (NO, Griess-reagent) were analysed.
T8 609-815 Sentence denotes After an incubation time of 72 h cell death was measured histomorphometrically (nuclear blebbing, NB) and release of glycosaminoglycans (GAG, DMMB assay) and nitric oxide (NO, Griess-reagent) were analysed.
T9 816-980 Sentence denotes Transcription levels (mRNA) of matrix degrading enzymes, collagen type X (COL10A1) and nitric oxide synthetase 2 (NOS2) were measured by quantitative real time PCR.
T9 816-980 Sentence denotes Transcription levels (mRNA) of matrix degrading enzymes, collagen type X (COL10A1) and nitric oxide synthetase 2 (NOS2) were measured by quantitative real time PCR.
T10 981-1095 Sentence denotes TNF-α-dependent formation of the aggrecanase-specific aggrecan neoepitope NITEGE was visualised by immunostaining.
T10 981-1095 Sentence denotes TNF-α-dependent formation of the aggrecanase-specific aggrecan neoepitope NITEGE was visualised by immunostaining.
T11 1096-1193 Sentence denotes Differences between groups were calculated using a one-way ANOVA with a Bonferroni post hoc test.
T11 1096-1193 Sentence denotes Differences between groups were calculated using a one-way ANOVA with a Bonferroni post hoc test.
T12 1194-1202 Sentence denotes RESULTS:
T12 1194-1202 Sentence denotes RESULTS:
T13 1203-1341 Sentence denotes Administration of IL-10 significantly prevented the TNF-α-related cell death (P .001), release of NO (P .003) and NOS2 expression (P .04).
T13 1203-1341 Sentence denotes Administration of IL-10 significantly prevented the TNF-α-related cell death (P .001), release of NO (P .003) and NOS2 expression (P .04).
T14 1342-1487 Sentence denotes Release of GAG fragments (P .001), NITEGE formation and expression of MMP3 (P .007), -13 (P .02) and ADAMTS4 (P .001) were significantly reduced.
T14 1342-1487 Sentence denotes Release of GAG fragments (P .001), NITEGE formation and expression of MMP3 (P .007), -13 (P .02) and ADAMTS4 (P .001) were significantly reduced.
T15 1488-1577 Sentence denotes The TNF-α-dependent increase in COL10A1 expression was also antagonized by IL-10 (P .02).
T15 1488-1577 Sentence denotes The TNF-α-dependent increase in COL10A1 expression was also antagonized by IL-10 (P .02).
T16 1578-1689 Sentence denotes CONCLUSION: IL-10 prevented crucial mechanisms of meniscal degeneration induced by a key cytokine of OA, TNF-α.
T16 1578-1689 Sentence denotes CONCLUSION: IL-10 prevented crucial mechanisms of meniscal degeneration induced by a key cytokine of OA, TNF-α.
T17 1690-1875 Sentence denotes Administration of IL-10 might improve the biological regeneration and provide a treatment approach in degenerative meniscus injuries and in conditions of post-traumatic sports injuries.
T17 1690-1875 Sentence denotes Administration of IL-10 might improve the biological regeneration and provide a treatment approach in degenerative meniscus injuries and in conditions of post-traumatic sports injuries.