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PubMed:28473469 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease.
T1 0-113 Sentence denotes An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease.
T2 114-241 Sentence denotes Inflammatory bowel diseases (IBDs) are a set of complex and debilitating diseases for which there is no satisfactory treatment.
T2 114-241 Sentence denotes Inflammatory bowel diseases (IBDs) are a set of complex and debilitating diseases for which there is no satisfactory treatment.
T3 242-344 Sentence denotes Recent studies have shown that small peptides show promise for reducing inflammation in models of IBD.
T3 242-344 Sentence denotes Recent studies have shown that small peptides show promise for reducing inflammation in models of IBD.
T4 345-528 Sentence denotes However, these small peptides are likely to be unstable and rapidly cleared from the circulation, and therefore, if not modified for better stability, represent non-viable drug leads.
T4 345-528 Sentence denotes However, these small peptides are likely to be unstable and rapidly cleared from the circulation, and therefore, if not modified for better stability, represent non-viable drug leads.
T5 529-687 Sentence denotes We hypothesized that improving the stability of these peptides by grafting them into a stable cyclic peptide scaffold may enhance their therapeutic potential.
T5 529-687 Sentence denotes We hypothesized that improving the stability of these peptides by grafting them into a stable cyclic peptide scaffold may enhance their therapeutic potential.
T6 688-877 Sentence denotes Using this approach, we have designed a novel cyclic peptide that comprises a small bioactive peptide from the annexin A1 protein grafted into a sunflower trypsin inhibitor cyclic scaffold.
T6 688-877 Sentence denotes Using this approach, we have designed a novel cyclic peptide that comprises a small bioactive peptide from the annexin A1 protein grafted into a sunflower trypsin inhibitor cyclic scaffold.
T7 878-952 Sentence denotes We used native chemical ligation to synthesize the grafted cyclic peptide.
T7 878-952 Sentence denotes We used native chemical ligation to synthesize the grafted cyclic peptide.
T8 953-1212 Sentence denotes This engineered cyclic peptide maintained the overall fold of the naturally occurring cyclic peptide, was more effective at reducing inflammation in a mouse model of acute colitis than the bioactive peptide alone, and showed enhanced stability in human serum.
T8 953-1212 Sentence denotes This engineered cyclic peptide maintained the overall fold of the naturally occurring cyclic peptide, was more effective at reducing inflammation in a mouse model of acute colitis than the bioactive peptide alone, and showed enhanced stability in human serum.
T9 1213-1397 Sentence denotes Our findings suggest that the use of cyclic peptides as structural backbones offers a promising approach for the treatment of IBD and potentially other chronic inflammatory conditions.
T9 1213-1397 Sentence denotes Our findings suggest that the use of cyclic peptides as structural backbones offers a promising approach for the treatment of IBD and potentially other chronic inflammatory conditions.