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PubMed:28473453 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-182 Sentence denotes In silico target network analysis of de novo-discovered, tick saliva-specific microRNAs reveals important combinatorial effects in their interference with vertebrate host physiology.
T1 0-182 Sentence denotes In silico target network analysis of de novo-discovered, tick saliva-specific microRNAs reveals important combinatorial effects in their interference with vertebrate host physiology.
T2 183-337 Sentence denotes The hard tick Ixodes ricinus is an important disease vector whose salivary secretions mediate blood-feeding success on vertebrate hosts, including humans.
T2 183-337 Sentence denotes The hard tick Ixodes ricinus is an important disease vector whose salivary secretions mediate blood-feeding success on vertebrate hosts, including humans.
T3 338-495 Sentence denotes Here we describe the expression profiles and downstream analysis of de novo-discovered microRNAs (miRNAs) expressed in I. ricinus salivary glands and saliva.
T3 338-495 Sentence denotes Here we describe the expression profiles and downstream analysis of de novo-discovered microRNAs (miRNAs) expressed in I. ricinus salivary glands and saliva.
T4 496-578 Sentence denotes Eleven tick-derived libraries were sequenced to produce 67,375,557 Illumina reads.
T4 496-578 Sentence denotes Eleven tick-derived libraries were sequenced to produce 67,375,557 Illumina reads.
T5 579-679 Sentence denotes De novo prediction yielded 67 bona fide miRNAs out of which 35 are currently not present in miRBase.
T5 579-679 Sentence denotes De novo prediction yielded 67 bona fide miRNAs out of which 35 are currently not present in miRBase.
T6 680-833 Sentence denotes We report for the first time the presence of microRNAs in tick saliva, obtaining furthermore molecular indicators that those might be of exosomal origin.
T6 680-833 Sentence denotes We report for the first time the presence of microRNAs in tick saliva, obtaining furthermore molecular indicators that those might be of exosomal origin.
T7 834-911 Sentence denotes Ten out of these microRNAs are at least 100 times more represented in saliva.
T7 834-911 Sentence denotes Ten out of these microRNAs are at least 100 times more represented in saliva.
T8 912-1086 Sentence denotes For the four most expressed microRNAs from this subset, we analyzed their combinatorial effects upon their host transcriptome using a novel in silico target network approach.
T8 912-1086 Sentence denotes For the four most expressed microRNAs from this subset, we analyzed their combinatorial effects upon their host transcriptome using a novel in silico target network approach.
T9 1087-1229 Sentence denotes We show that only the inclusion of combinatorial effects reveals the functions in important pathways related to inflammation and pain sensing.
T9 1087-1229 Sentence denotes We show that only the inclusion of combinatorial effects reveals the functions in important pathways related to inflammation and pain sensing.
T10 1230-1388 Sentence denotes A control set of highly abundant microRNAs in both saliva and salivary glands indicates no significant pathways and a far lower number of shared target genes.
T10 1230-1388 Sentence denotes A control set of highly abundant microRNAs in both saliva and salivary glands indicates no significant pathways and a far lower number of shared target genes.
T11 1389-1680 Sentence denotes Therefore, the analysis of miRNAs from pure tick saliva strongly supports the hypothesis that tick saliva miRNAs can modulate vertebrate host homeostasis and represents the first direct evidence of tick miRNA-mediated regulation of vertebrate host gene expression at the tick-host interface.
T11 1389-1680 Sentence denotes Therefore, the analysis of miRNAs from pure tick saliva strongly supports the hypothesis that tick saliva miRNAs can modulate vertebrate host homeostasis and represents the first direct evidence of tick miRNA-mediated regulation of vertebrate host gene expression at the tick-host interface.
T12 1681-1873 Sentence denotes As such, the herein described miRNAs may support future drug discovery and development projects that will also experimentally question their predicted molecular targets in the vertebrate host.
T12 1681-1873 Sentence denotes As such, the herein described miRNAs may support future drug discovery and development projects that will also experimentally question their predicted molecular targets in the vertebrate host.