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PubMed:28416580 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-69 Sentence denotes A TSPO ligand attenuates brain injury after intracerebral hemorrhage.
T1 0-69 Sentence denotes A TSPO ligand attenuates brain injury after intracerebral hemorrhage.
T2 70-154 Sentence denotes Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment.
T2 70-154 Sentence denotes Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment.
T3 155-318 Sentence denotes After ICH, the immediate infiltration of leukocytes and activation of microglia are accompanied by a rapid up-regulation of the 18-kDa translocator protein (TSPO).
T3 155-318 Sentence denotes After ICH, the immediate infiltration of leukocytes and activation of microglia are accompanied by a rapid up-regulation of the 18-kDa translocator protein (TSPO).
T4 319-416 Sentence denotes TSPO ligands have shown anti-inflammatory and neuroprotective properties in models of CNS injury.
T4 319-416 Sentence denotes TSPO ligands have shown anti-inflammatory and neuroprotective properties in models of CNS injury.
T5 417-544 Sentence denotes In this study, we determined the impact of a TSPO ligand, etifoxine, on brain injury and inflammation in 2 mouse models of ICH.
T5 417-544 Sentence denotes In this study, we determined the impact of a TSPO ligand, etifoxine, on brain injury and inflammation in 2 mouse models of ICH.
T6 545-695 Sentence denotes TSPO was up-regulated in Iba1(+) cells from brains of patients with ICH and in CD11b(+)CD45(int) cells from mice subjected to collagenase-induced ICH.
T6 545-695 Sentence denotes TSPO was up-regulated in Iba1(+) cells from brains of patients with ICH and in CD11b(+)CD45(int) cells from mice subjected to collagenase-induced ICH.
T7 696-847 Sentence denotes Etifoxine significantly reduced neurodeficits and perihematomal brain edema after ICH induction by injection of either autologous blood or collagenase.
T7 696-847 Sentence denotes Etifoxine significantly reduced neurodeficits and perihematomal brain edema after ICH induction by injection of either autologous blood or collagenase.
T8 848-1019 Sentence denotes In collagenase-induced ICH mice, the protection of etifoxine was associated with reduced leukocyte infiltration into the brain and microglial production of IL-6 and TNF-α.
T8 848-1019 Sentence denotes In collagenase-induced ICH mice, the protection of etifoxine was associated with reduced leukocyte infiltration into the brain and microglial production of IL-6 and TNF-α.
T9 1020-1095 Sentence denotes Etifoxine improved blood-brain barrier integrity and diminished cell death.
T9 1020-1095 Sentence denotes Etifoxine improved blood-brain barrier integrity and diminished cell death.
T10 1096-1242 Sentence denotes Notably, the protective effect of etifoxine was abolished in mice depleted of microglia by using a colony-stimulating factor 1 receptor inhibitor.
T10 1096-1242 Sentence denotes Notably, the protective effect of etifoxine was abolished in mice depleted of microglia by using a colony-stimulating factor 1 receptor inhibitor.
T11 1243-1348 Sentence denotes These results indicate that the TSPO ligand etifoxine attenuates brain injury and inflammation after ICH.
T11 1243-1348 Sentence denotes These results indicate that the TSPO ligand etifoxine attenuates brain injury and inflammation after ICH.
T12 1349-1460 Sentence denotes TSPO may be a viable therapeutic target that requires further investigations in ICH.-Li, M., Ren, H., Sheth, K.
T12 1349-1460 Sentence denotes TSPO may be a viable therapeutic target that requires further investigations in ICH.-Li, M., Ren, H., Sheth, K.
T13 1461-1484 Sentence denotes N., Shi, F.-D., Liu, Q.
T13 1461-1484 Sentence denotes N., Shi, F.-D., Liu, Q.
T14 1485-1554 Sentence denotes A TSPO ligand attenuates brain injury after intracerebral hemorrhage.
T14 1485-1554 Sentence denotes A TSPO ligand attenuates brain injury after intracerebral hemorrhage.