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PubMed:27959382 JSONTXT 27 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes Bach1 siRNA attenuates bleomycin-induced pulmonary fibrosis by modulating oxidative stress in mice.
T1 0-99 Sentence denotes Bach1 siRNA attenuates bleomycin-induced pulmonary fibrosis by modulating oxidative stress in mice.
T2 100-170 Sentence denotes Oxidative stress plays an essential role in inflammation and fibrosis.
T2 100-170 Sentence denotes Oxidative stress plays an essential role in inflammation and fibrosis.
T3 171-338 Sentence denotes Bach1 is an important transcriptional repressor that acts by modulating oxidative stress and represents a potential target in the treatment of pulmonary fibrosis (PF).
T3 171-338 Sentence denotes Bach1 is an important transcriptional repressor that acts by modulating oxidative stress and represents a potential target in the treatment of pulmonary fibrosis (PF).
T4 339-553 Sentence denotes In this study, we knocked down Bach1 using adenovirus-mediated small interfering RNA (siRNA) to determine whether the use of Bach1 siRNA is an effective therapeutic strategy in mice with bleomycin (BLM)‑induced PF.
T4 339-553 Sentence denotes In this study, we knocked down Bach1 using adenovirus-mediated small interfering RNA (siRNA) to determine whether the use of Bach1 siRNA is an effective therapeutic strategy in mice with bleomycin (BLM)‑induced PF.
T5 554-805 Sentence denotes Mouse lung fibroblasts (MLFs) were incubated with transforming growth factor (TGF)-β1 (5 ng/ml) and subsequently infected with recombined adenovirus-like Bach1 siRNA1 and Bach1 siRNA2, while an empty adenovirus vector was used as the negative control.
T5 554-805 Sentence denotes Mouse lung fibroblasts (MLFs) were incubated with transforming growth factor (TGF)-β1 (5 ng/ml) and subsequently infected with recombined adenovirus-like Bach1 siRNA1 and Bach1 siRNA2, while an empty adenovirus vector was used as the negative control.
T6 806-903 Sentence denotes The selected Bach1 siRNA with higher interference efficiency was used for the animal experiments.
T6 806-903 Sentence denotes The selected Bach1 siRNA with higher interference efficiency was used for the animal experiments.
T7 904-1028 Sentence denotes A mouse model of BLM-induced PF was established, and Bach1 siRNA (1x109 pfu) was administered to the mice via the tail vein.
T7 904-1028 Sentence denotes A mouse model of BLM-induced PF was established, and Bach1 siRNA (1x109 pfu) was administered to the mice via the tail vein.
T8 1029-1137 Sentence denotes The results revealed that the Bach1 mRNA and protein levels were significantly downregulated by Bach1 siRNA.
T8 1029-1137 Sentence denotes The results revealed that the Bach1 mRNA and protein levels were significantly downregulated by Bach1 siRNA.
T9 1138-1413 Sentence denotes Furthermore, the MLFs infected with Bach1 siRNA exhibited increased mRNA and protein expression levels of heme oxygenase-1 and glutathione peroxidase 1, but decreased levels of TGF-β1 and interleukin-6 in the cell supernatants compared with the cells exposed to TGF-β1 alone.
T9 1138-1413 Sentence denotes Furthermore, the MLFs infected with Bach1 siRNA exhibited increased mRNA and protein expression levels of heme oxygenase-1 and glutathione peroxidase 1, but decreased levels of TGF-β1 and interleukin-6 in the cell supernatants compared with the cells exposed to TGF-β1 alone.
T10 1414-1578 Sentence denotes Bach1 knockdown by siRNA also enhanced the expression of antioxidant factors, but suppressed that of fibrosis‑related cytokines in mice compared with the BLM group.
T10 1414-1578 Sentence denotes Bach1 knockdown by siRNA also enhanced the expression of antioxidant factors, but suppressed that of fibrosis‑related cytokines in mice compared with the BLM group.
T11 1579-1795 Sentence denotes Finally, the inflammatory infiltration of alveolar and interstitial cells and the destruction of lung structure were significantly attenuated in the mide administered Bach1 siRNA compared with those in the BLM group.
T11 1579-1795 Sentence denotes Finally, the inflammatory infiltration of alveolar and interstitial cells and the destruction of lung structure were significantly attenuated in the mide administered Bach1 siRNA compared with those in the BLM group.
T12 1796-1909 Sentence denotes On the whole, our findings demonstrate that Bach1 siRNA exerts protective effects against BLM-induced PF in mice.
T12 1796-1909 Sentence denotes On the whole, our findings demonstrate that Bach1 siRNA exerts protective effects against BLM-induced PF in mice.
T13 1910-2009 Sentence denotes Our data may provide the basis for the development of novel targeted therapeutic strategies for PF.
T13 1910-2009 Sentence denotes Our data may provide the basis for the development of novel targeted therapeutic strategies for PF.