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PubMed:27866394 JSONTXT 27 Projects

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Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Repeated otilonium bromide administration prevents neurotransmitter changes in colon of rats underwent to wrap restraint stress.
T1 0-128 Sentence denotes Repeated otilonium bromide administration prevents neurotransmitter changes in colon of rats underwent to wrap restraint stress.
T2 129-244 Sentence denotes Otilonium bromide (OB) is a spasmolytic drug successfully used for the treatment of irritable bowel syndrome (IBS).
T2 129-244 Sentence denotes Otilonium bromide (OB) is a spasmolytic drug successfully used for the treatment of irritable bowel syndrome (IBS).
T3 245-385 Sentence denotes Its efficacy has been attributed to the block of L- and T-type Ca(2+) channels and muscarinic and tachykinin receptors in the smooth muscle.
T3 245-385 Sentence denotes Its efficacy has been attributed to the block of L- and T-type Ca(2+) channels and muscarinic and tachykinin receptors in the smooth muscle.
T4 386-531 Sentence denotes Furthermore, in healthy rats, repeated OB administration modified neurotransmitter expression and function suggesting other mechanisms of action.
T4 386-531 Sentence denotes Furthermore, in healthy rats, repeated OB administration modified neurotransmitter expression and function suggesting other mechanisms of action.
T5 532-803 Sentence denotes On this basis, we investigated whether repeated OB treatment prevented the functional and neurochemical changes observed in the colon of rats underwent to wrap restrain stress (WRS) a psychosocial stressor considered suitable to reproduce the main IBS signs and symptoms.
T5 532-803 Sentence denotes On this basis, we investigated whether repeated OB treatment prevented the functional and neurochemical changes observed in the colon of rats underwent to wrap restrain stress (WRS) a psychosocial stressor considered suitable to reproduce the main IBS signs and symptoms.
T6 804-944 Sentence denotes In control, WRS and OB/WRS rats functional parameters were measured in vivo and morphological investigations were done ex vivo in the colon.
T6 804-944 Sentence denotes In control, WRS and OB/WRS rats functional parameters were measured in vivo and morphological investigations were done ex vivo in the colon.
T7 945-1036 Sentence denotes The results showed that OB counteracts most of the neurotransmitters changes caused by WRS.
T7 945-1036 Sentence denotes The results showed that OB counteracts most of the neurotransmitters changes caused by WRS.
T8 1037-1183 Sentence denotes In particular, the drug prevents the decrease in SP-, NK1r-, nNOS-, VIP-, and S100β-immunoreactivity (IR) and the increase in CGRP-, and CRF1r-IR.
T8 1037-1183 Sentence denotes In particular, the drug prevents the decrease in SP-, NK1r-, nNOS-, VIP-, and S100β-immunoreactivity (IR) and the increase in CGRP-, and CRF1r-IR.
T9 1184-1343 Sentence denotes On the contrary, OB does not affect the increase in CRF2r-IR neurons observed in WRS rats and does not interfere with the mild mucosal inflammation due to WRS.
T9 1184-1343 Sentence denotes On the contrary, OB does not affect the increase in CRF2r-IR neurons observed in WRS rats and does not interfere with the mild mucosal inflammation due to WRS.
T10 1344-1469 Sentence denotes Finally, OB per se increases the Mr2 expression in the muscle wall and decreases the number of the myenteric ChAT-IR neurons.
T10 1344-1469 Sentence denotes Finally, OB per se increases the Mr2 expression in the muscle wall and decreases the number of the myenteric ChAT-IR neurons.
T11 1470-1591 Sentence denotes Functional findings show a significantly reduction in the number of spontaneous abdominal contraction in OB treated rats.
T11 1470-1591 Sentence denotes Functional findings show a significantly reduction in the number of spontaneous abdominal contraction in OB treated rats.
T12 1592-1751 Sentence denotes The ability of OB to block L-type Ca(2+) channels, also expressed by enteric neurons, might represent a possible mechanism through which OB exerts its actions.
T12 1592-1751 Sentence denotes The ability of OB to block L-type Ca(2+) channels, also expressed by enteric neurons, might represent a possible mechanism through which OB exerts its actions.