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PubMed:27702777 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1 0-81 Sentence denotes Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs.
T1 0-81 Sentence denotes Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs.
T2 82-186 Sentence denotes Acidic mammalian chitinase (AMCase) is implicated in asthma, allergic inflammation, and food processing.
T2 82-186 Sentence denotes Acidic mammalian chitinase (AMCase) is implicated in asthma, allergic inflammation, and food processing.
T3 187-279 Sentence denotes Little is known about genetic and evolutional regulation of chitinolytic activity of AMCase.
T3 187-279 Sentence denotes Little is known about genetic and evolutional regulation of chitinolytic activity of AMCase.
T4 280-497 Sentence denotes Here, we relate human AMCase polymorphisms to the mouse AMCase, and show that the highly active variants encoded by nonsynonymous single-nucleotide polymorphisms (nsSNPs) are consistent with the mouse AMCase sequence.
T4 280-497 Sentence denotes Here, we relate human AMCase polymorphisms to the mouse AMCase, and show that the highly active variants encoded by nonsynonymous single-nucleotide polymorphisms (nsSNPs) are consistent with the mouse AMCase sequence.
T5 498-615 Sentence denotes The chitinolytic activity of the recombinant human AMCase was significantly lower than that of the mouse counterpart.
T5 498-615 Sentence denotes The chitinolytic activity of the recombinant human AMCase was significantly lower than that of the mouse counterpart.
T6 616-821 Sentence denotes By creating mouse-human chimeric AMCase protein we found that the presence of the N-terminal region of human AMCase containing conserved active site residues reduced the enzymatic activity of the molecule.
T6 616-821 Sentence denotes By creating mouse-human chimeric AMCase protein we found that the presence of the N-terminal region of human AMCase containing conserved active site residues reduced the enzymatic activity of the molecule.
T7 822-1020 Sentence denotes We were able to significantly increase the activity of human AMCase by amino acid substitutions encoded by nsSNPs (N45, D47, and R61) with those conserved in the mouse homologue (D45, N47, and M61).
T7 822-1020 Sentence denotes We were able to significantly increase the activity of human AMCase by amino acid substitutions encoded by nsSNPs (N45, D47, and R61) with those conserved in the mouse homologue (D45, N47, and M61).
T8 1021-1110 Sentence denotes For abolition of the mouse AMCase activity, introduction of M61R mutation was sufficient.
T8 1021-1110 Sentence denotes For abolition of the mouse AMCase activity, introduction of M61R mutation was sufficient.
T9 1111-1207 Sentence denotes M61 is conserved in most of primates other than human and orangutan as well as in other mammals.
T9 1111-1207 Sentence denotes M61 is conserved in most of primates other than human and orangutan as well as in other mammals.
T10 1208-1377 Sentence denotes Orangutan has I61 substitution, which also markedly reduced the activity of the mouse AMCase, indicating that the M61 is a crucial residue for the chitinolytic activity.
T10 1208-1377 Sentence denotes Orangutan has I61 substitution, which also markedly reduced the activity of the mouse AMCase, indicating that the M61 is a crucial residue for the chitinolytic activity.
T11 1378-1603 Sentence denotes Altogether, our data suggest that human AMCase has lost its chitinolytic activity by integration of nsSNPs during evolution and that the enzyme can be reactivated by introducing amino acids conserved in the mouse counterpart.
T11 1378-1603 Sentence denotes Altogether, our data suggest that human AMCase has lost its chitinolytic activity by integration of nsSNPs during evolution and that the enzyme can be reactivated by introducing amino acids conserved in the mouse counterpart.