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PubMed:27693549 JSONTXT 6 Projects

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Id Subject Object Predicate Lexical cue
T1 0-139 Sentence denotes Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease.
T1 0-139 Sentence denotes Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease.
T2 140-281 Sentence denotes Neuroinflammation involves the activation of glial cells, which is associated to the progression of neurodegeneration in Parkinson's disease.
T2 140-281 Sentence denotes Neuroinflammation involves the activation of glial cells, which is associated to the progression of neurodegeneration in Parkinson's disease.
T3 282-551 Sentence denotes Recently, we and other researchers demonstrated that dopamine receptor D3 (D3R)-deficient mice are completely refractory to neuroinflammation and consequent neurodegeneration associated to the acute intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
T3 282-551 Sentence denotes Recently, we and other researchers demonstrated that dopamine receptor D3 (D3R)-deficient mice are completely refractory to neuroinflammation and consequent neurodegeneration associated to the acute intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
T4 552-760 Sentence denotes In this study we examined the therapeutic potential and underlying mechanism of a D3R-selective antagonist, PG01037, in mice intoxicated with a chronic regime of administration of MPTP and probenecid (MPTPp).
T4 552-760 Sentence denotes In this study we examined the therapeutic potential and underlying mechanism of a D3R-selective antagonist, PG01037, in mice intoxicated with a chronic regime of administration of MPTP and probenecid (MPTPp).
T5 761-950 Sentence denotes Biodistribution analysis indicated that intraperitoneally administered PG01037 crosses the blood-brain barrier and reaches the highest concentration in the brain 40 min after the injection.
T5 761-950 Sentence denotes Biodistribution analysis indicated that intraperitoneally administered PG01037 crosses the blood-brain barrier and reaches the highest concentration in the brain 40 min after the injection.
T6 951-1045 Sentence denotes Furthermore, the drug was preferentially distributed to the brain in comparison to the plasma.
T6 951-1045 Sentence denotes Furthermore, the drug was preferentially distributed to the brain in comparison to the plasma.
T7 1046-1429 Sentence denotes Treatment of MPTPp-intoxicated mice with PG01037 (30 mg/kg, administrated twice a week for five weeks) attenuated the loss of dopaminergic neurons in the substantia nigra pars compacta, as evaluated by stereological analysis, and the loss of striatal dopaminergic terminals, as determined by densitometric analyses of tyrosine hydroxylase and dopamine transporter immunoreactivities.
T7 1046-1429 Sentence denotes Treatment of MPTPp-intoxicated mice with PG01037 (30 mg/kg, administrated twice a week for five weeks) attenuated the loss of dopaminergic neurons in the substantia nigra pars compacta, as evaluated by stereological analysis, and the loss of striatal dopaminergic terminals, as determined by densitometric analyses of tyrosine hydroxylase and dopamine transporter immunoreactivities.
T8 1430-1533 Sentence denotes Accordingly, the treatment resulted in significant improvement of motor performance of injured animals.
T8 1430-1533 Sentence denotes Accordingly, the treatment resulted in significant improvement of motor performance of injured animals.
T9 1534-1715 Sentence denotes Interestingly, the therapeutic dose of PG01037 exacerbated astrogliosis and resulted in increased ramification density of microglial cells in the striatum of MPTPp-intoxicated mice.
T9 1534-1715 Sentence denotes Interestingly, the therapeutic dose of PG01037 exacerbated astrogliosis and resulted in increased ramification density of microglial cells in the striatum of MPTPp-intoxicated mice.
T10 1716-1859 Sentence denotes Further analyses suggested that D3R expressed in astrocytes favours a beneficial astrogliosis with anti-inflammatory consequences on microglia.
T10 1716-1859 Sentence denotes Further analyses suggested that D3R expressed in astrocytes favours a beneficial astrogliosis with anti-inflammatory consequences on microglia.
T11 1860-2119 Sentence denotes Our findings indicate that D3R-antagonism exerts a therapeutic effect in parkinsonian animals by reducing the loss of dopaminergic neurons in the nigrostriatal pathway, alleviating motor impairments and modifying the pro-inflammatory phenotype of glial cells.
T11 1860-2119 Sentence denotes Our findings indicate that D3R-antagonism exerts a therapeutic effect in parkinsonian animals by reducing the loss of dopaminergic neurons in the nigrostriatal pathway, alleviating motor impairments and modifying the pro-inflammatory phenotype of glial cells.