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PubMed:27470399 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome:
T1 0-89 Sentence denotes Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome:
T2 90-143 Sentence denotes A post-hoc analysis of a randomized controlled trial.
T2 90-143 Sentence denotes A post-hoc analysis of a randomized controlled trial.
T3 144-155 Sentence denotes BACKGROUND:
T3 144-155 Sentence denotes BACKGROUND:
T4 156-270 Sentence denotes Cytokines are involved in the development of metabolic abnormalities that may result in metabolic syndrome (MetS).
T4 156-270 Sentence denotes Cytokines are involved in the development of metabolic abnormalities that may result in metabolic syndrome (MetS).
T5 271-459 Sentence denotes Since curcumin has shown anti-inflammatory properties, the aim of this study was to evaluate the effect of curcumin supplementation on serum cytokines concentrations in subjects with MetS.
T5 271-459 Sentence denotes Since curcumin has shown anti-inflammatory properties, the aim of this study was to evaluate the effect of curcumin supplementation on serum cytokines concentrations in subjects with MetS.
T6 460-468 Sentence denotes METHODS:
T6 460-468 Sentence denotes METHODS:
T7 469-719 Sentence denotes This study was a post-hoc analysis of a randomized controlled trial in which males and females with diagnosis of MetS, according to the criteria defined by the National Cholesterol Education Program Adult Treatment Panel III guidelines, were studied.
T7 469-719 Sentence denotes This study was a post-hoc analysis of a randomized controlled trial in which males and females with diagnosis of MetS, according to the criteria defined by the National Cholesterol Education Program Adult Treatment Panel III guidelines, were studied.
T8 720-870 Sentence denotes Subjects who met the inclusion criteria were randomly assigned to either curcumin (daily dose of 1g/day) or a matched placebo for a period of 8 weeks.
T8 720-870 Sentence denotes Subjects who met the inclusion criteria were randomly assigned to either curcumin (daily dose of 1g/day) or a matched placebo for a period of 8 weeks.
T9 871-879 Sentence denotes RESULTS:
T9 871-879 Sentence denotes RESULTS:
T10 880-980 Sentence denotes One hundred and seventeen subjects were assigned to either curcumin (n=59) or placebo (n=58) groups.
T10 880-980 Sentence denotes One hundred and seventeen subjects were assigned to either curcumin (n=59) or placebo (n=58) groups.
T11 981-1136 Sentence denotes Within-group analysis revealed significant reductions in serum concentrations of TNF-α, IL-6, TGF-β and MCP-1 following curcumin supplementation (p<0.001).
T11 981-1136 Sentence denotes Within-group analysis revealed significant reductions in serum concentrations of TNF-α, IL-6, TGF-β and MCP-1 following curcumin supplementation (p<0.001).
T12 1137-1310 Sentence denotes In the placebo group, serum levels of TGF-β were decreased (p=0.003) but those of IL-6 (p=0.735), TNF-α (p=0.138) and MCP-1 (p=0.832) remained unaltered by the end of study.
T12 1137-1310 Sentence denotes In the placebo group, serum levels of TGF-β were decreased (p=0.003) but those of IL-6 (p=0.735), TNF-α (p=0.138) and MCP-1 (p=0.832) remained unaltered by the end of study.
T13 1311-1482 Sentence denotes Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-α, IL-6, TGF-β and MCP-1 in the curcumin versus placebo group (p<0.001).
T13 1311-1482 Sentence denotes Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-α, IL-6, TGF-β and MCP-1 in the curcumin versus placebo group (p<0.001).
T14 1483-1710 Sentence denotes Apart from IL-6, changes in other parameters remained statistically significant after adjustment for potential confounders including changes in serum lipids and glucose levels, and baseline serum concentration of the cytokines.
T14 1483-1710 Sentence denotes Apart from IL-6, changes in other parameters remained statistically significant after adjustment for potential confounders including changes in serum lipids and glucose levels, and baseline serum concentration of the cytokines.
T15 1711-1722 Sentence denotes CONCLUSION:
T15 1711-1722 Sentence denotes CONCLUSION:
T16 1723-1887 Sentence denotes Results of the present study suggest that curcumin supplementation significantly decreases serum concentrations of pro-inflammatory cytokines in subjects with MetS.
T16 1723-1887 Sentence denotes Results of the present study suggest that curcumin supplementation significantly decreases serum concentrations of pro-inflammatory cytokines in subjects with MetS.