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PubMed:26937641 JSONTXT 27 Projects

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Id Subject Object Predicate Lexical cue
T1 0-103 Sentence denotes Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.
T1 0-103 Sentence denotes Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.
T2 104-228 Sentence denotes Serum amyloid A (SAA) is an evolutionary highly conserved acute phase protein that is predominantly secreted by hepatocytes.
T2 104-228 Sentence denotes Serum amyloid A (SAA) is an evolutionary highly conserved acute phase protein that is predominantly secreted by hepatocytes.
T3 229-311 Sentence denotes However, its role in liver injury and fibrogenesis has not been elucidated so far.
T3 229-311 Sentence denotes However, its role in liver injury and fibrogenesis has not been elucidated so far.
T4 312-437 Sentence denotes In this study, we determined the effects of SAA on hepatic stellate cells (HSCs), the main fibrogenic cell type of the liver.
T4 312-437 Sentence denotes In this study, we determined the effects of SAA on hepatic stellate cells (HSCs), the main fibrogenic cell type of the liver.
T5 438-607 Sentence denotes Serum amyloid A potently activated IκB kinase, c-Jun N-terminal kinase (JNK), Erk and Akt and enhanced NF-κB-dependent luciferase activity in primary human and rat HSCs.
T5 438-607 Sentence denotes Serum amyloid A potently activated IκB kinase, c-Jun N-terminal kinase (JNK), Erk and Akt and enhanced NF-κB-dependent luciferase activity in primary human and rat HSCs.
T6 608-714 Sentence denotes Serum amyloid A induced the transcription of MCP-1, RANTES and MMP9 in an NF-κB- and JNK-dependent manner.
T6 608-714 Sentence denotes Serum amyloid A induced the transcription of MCP-1, RANTES and MMP9 in an NF-κB- and JNK-dependent manner.
T7 715-866 Sentence denotes Blockade of NF-κB revealed cytotoxic effects of SAA in primary HSCs with signs of apoptosis such as caspase 3 and PARP cleavage and Annexin V staining.
T7 715-866 Sentence denotes Blockade of NF-κB revealed cytotoxic effects of SAA in primary HSCs with signs of apoptosis such as caspase 3 and PARP cleavage and Annexin V staining.
T8 867-954 Sentence denotes Serum amyloid A induced HSC proliferation, which depended on JNK, Erk and Akt activity.
T8 867-954 Sentence denotes Serum amyloid A induced HSC proliferation, which depended on JNK, Erk and Akt activity.
T9 955-1073 Sentence denotes In primary hepatocytes, SAA also activated MAP kinases, but did not induce relevant cell death after NF-κB inhibition.
T9 955-1073 Sentence denotes In primary hepatocytes, SAA also activated MAP kinases, but did not induce relevant cell death after NF-κB inhibition.
T10 1074-1213 Sentence denotes In two models of hepatic fibrogenesis, CCl4 treatment and bile duct ligation, hepatic mRNA levels of SAA1 and SAA3 were strongly increased.
T10 1074-1213 Sentence denotes In two models of hepatic fibrogenesis, CCl4 treatment and bile duct ligation, hepatic mRNA levels of SAA1 and SAA3 were strongly increased.
T11 1214-1378 Sentence denotes In conclusion, SAA may modulate fibrogenic responses in the liver in a positive and negative fashion by inducing inflammation, proliferation and cell death in HSCs.
T11 1214-1378 Sentence denotes In conclusion, SAA may modulate fibrogenic responses in the liver in a positive and negative fashion by inducing inflammation, proliferation and cell death in HSCs.