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PubMed:26769134 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-145 Sentence denotes Caenorhabditis elegans susceptibility to gut Enterococcus faecalis infection is associated with fat metabolism and epithelial junction integrity.
T1 0-145 Sentence denotes Caenorhabditis elegans susceptibility to gut Enterococcus faecalis infection is associated with fat metabolism and epithelial junction integrity.
T2 146-157 Sentence denotes BACKGROUND:
T2 146-157 Sentence denotes BACKGROUND:
T3 158-297 Sentence denotes Gut bacteria-host interactions have been implicated in the pathogenesis of numerous human diseases, but few mechanisms have been described.
T3 158-297 Sentence denotes Gut bacteria-host interactions have been implicated in the pathogenesis of numerous human diseases, but few mechanisms have been described.
T4 298-526 Sentence denotes The genetically tractable nematode worm Caenorhabditis elegans can be infected with pathogenic bacteria, such as the human gut commensal Enterococcus faecalis, via feeding, making it a good model for studying these interactions.
T4 298-526 Sentence denotes The genetically tractable nematode worm Caenorhabditis elegans can be infected with pathogenic bacteria, such as the human gut commensal Enterococcus faecalis, via feeding, making it a good model for studying these interactions.
T5 527-535 Sentence denotes RESULTS:
T5 527-535 Sentence denotes RESULTS:
T6 536-804 Sentence denotes An RNAi screen of 17 worm candidate genes revealed that knockdown of the transcription factor nhr-49, a master regulator of fat metabolism, shortens worm lifespan upon infection with E. faecalis (and other potentially pathogenic bacteria) compared to Escherichia coli.
T6 536-804 Sentence denotes An RNAi screen of 17 worm candidate genes revealed that knockdown of the transcription factor nhr-49, a master regulator of fat metabolism, shortens worm lifespan upon infection with E. faecalis (and other potentially pathogenic bacteria) compared to Escherichia coli.
T7 805-1006 Sentence denotes The functional similarity of nhr-49 to the mammalian peroxisome proliferator-activated receptors (PPARs) suggests that this is mediated through a link between fatty acid metabolism and innate immunity.
T7 805-1006 Sentence denotes The functional similarity of nhr-49 to the mammalian peroxisome proliferator-activated receptors (PPARs) suggests that this is mediated through a link between fatty acid metabolism and innate immunity.
T8 1007-1274 Sentence denotes In addition, knockdown of either dlg-1 or ajm-1, which encode physically interacting proteins in the C. elegans epithelial junction, also reduces worm lifespan upon E. faecalis challenge, demonstrating the importance of the intestinal epithelium as an immune barrier.
T8 1007-1274 Sentence denotes In addition, knockdown of either dlg-1 or ajm-1, which encode physically interacting proteins in the C. elegans epithelial junction, also reduces worm lifespan upon E. faecalis challenge, demonstrating the importance of the intestinal epithelium as an immune barrier.
T9 1275-1287 Sentence denotes CONCLUSIONS:
T9 1275-1287 Sentence denotes CONCLUSIONS:
T10 1288-1582 Sentence denotes The protective roles identified for nhr-49, dlg-1, and ajm-1 suggest mechanistic interactions between the gut microbiota, host fatty acid metabolism, innate immunity, and epithelial junction integrity that are remarkably similar to those implicated in human metabolic and inflammatory diseases.
T10 1288-1582 Sentence denotes The protective roles identified for nhr-49, dlg-1, and ajm-1 suggest mechanistic interactions between the gut microbiota, host fatty acid metabolism, innate immunity, and epithelial junction integrity that are remarkably similar to those implicated in human metabolic and inflammatory diseases.