| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-109 |
Sentence |
denotes |
Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis. |
| T1 |
0-109 |
Sentence |
denotes |
Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis. |
| T2 |
110-121 |
Sentence |
denotes |
OBJECTIVES: |
| T2 |
110-121 |
Sentence |
denotes |
OBJECTIVES: |
| T3 |
122-276 |
Sentence |
denotes |
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by persistent synovitis, ultimately leading to cartilage and bone degeneration. |
| T3 |
122-276 |
Sentence |
denotes |
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by persistent synovitis, ultimately leading to cartilage and bone degeneration. |
| T4 |
277-369 |
Sentence |
denotes |
Natural Killer cells and CD28 null T-cells are suspected as role players in RA pathogenesis. |
| T4 |
277-369 |
Sentence |
denotes |
Natural Killer cells and CD28 null T-cells are suspected as role players in RA pathogenesis. |
| T5 |
370-531 |
Sentence |
denotes |
These cells are similar in feature and function, as they both exert their cytotoxic effect via Killer Cell Immunoglobulin- Like Receptors (KIR) on their surface. |
| T5 |
370-531 |
Sentence |
denotes |
These cells are similar in feature and function, as they both exert their cytotoxic effect via Killer Cell Immunoglobulin- Like Receptors (KIR) on their surface. |
| T6 |
532-635 |
Sentence |
denotes |
KIR genes have either an inhibitory or activating effect depending on their intracytoplasmic structure. |
| T6 |
532-635 |
Sentence |
denotes |
KIR genes have either an inhibitory or activating effect depending on their intracytoplasmic structure. |
| T7 |
636-776 |
Sentence |
denotes |
Herein we genotyped 16 KIR genes, 3 pseudo genes and 6 HLA class І genes as their corresponding ligands in RA patients and control subjects. |
| T7 |
636-776 |
Sentence |
denotes |
Herein we genotyped 16 KIR genes, 3 pseudo genes and 6 HLA class І genes as their corresponding ligands in RA patients and control subjects. |
| T8 |
777-785 |
Sentence |
denotes |
METHODS: |
| T8 |
777-785 |
Sentence |
denotes |
METHODS: |
| T9 |
786-941 |
Sentence |
denotes |
In this case-control study, KIR and HLA genes were genotyped in 400 RA patients and 372 matched healthy controls using sequence-specific primers (SSP-PCR). |
| T9 |
786-941 |
Sentence |
denotes |
In this case-control study, KIR and HLA genes were genotyped in 400 RA patients and 372 matched healthy controls using sequence-specific primers (SSP-PCR). |
| T10 |
942-1022 |
Sentence |
denotes |
Differences in the frequency of genes and haplotypes were determined by χ² test. |
| T10 |
942-1022 |
Sentence |
denotes |
Differences in the frequency of genes and haplotypes were determined by χ² test. |
| T11 |
1023-1122 |
Sentence |
denotes |
RESULTS: KIR2DL2, 2DL5a, 2DL5b and activating KIR: KIR2DS5 and 3DS1 were all protective against RA. |
| T11 |
1023-1122 |
Sentence |
denotes |
RESULTS: KIR2DL2, 2DL5a, 2DL5b and activating KIR: KIR2DS5 and 3DS1 were all protective against RA. |
| T12 |
1123-1266 |
Sentence |
denotes |
KIR2DL5 removal from a full Inhibitory KIR haplotype converted the mild protection (OR = 0.56) to a powerful predisposition to RA (OR = 16.47). |
| T12 |
1123-1266 |
Sentence |
denotes |
KIR2DL5 removal from a full Inhibitory KIR haplotype converted the mild protection (OR = 0.56) to a powerful predisposition to RA (OR = 16.47). |
| T13 |
1267-1291 |
Sentence |
denotes |
Inhibitory haplotype No. |
| T13 |
1267-1291 |
Sentence |
denotes |
Inhibitory haplotype No. |
| T14 |
1292-1398 |
Sentence |
denotes |
7 comprising KIR2DL5 in the absence of KIR2DL1 and KIR2DL3 confers a 14-fold protective effect against RA. |
| T14 |
1292-1398 |
Sentence |
denotes |
7 comprising KIR2DL5 in the absence of KIR2DL1 and KIR2DL3 confers a 14-fold protective effect against RA. |
| T15 |
1399-1410 |
Sentence |
denotes |
CONCLUSION: |
| T15 |
1399-1410 |
Sentence |
denotes |
CONCLUSION: |
| T16 |
1411-1464 |
Sentence |
denotes |
Individuals carrying the inhibitory KIR haplotype No. |
| T16 |
1411-1464 |
Sentence |
denotes |
Individuals carrying the inhibitory KIR haplotype No. |
| T17 |
1465-1512 |
Sentence |
denotes |
6 have a high potential risk for developing RA. |
| T17 |
1465-1512 |
Sentence |
denotes |
6 have a high potential risk for developing RA. |