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PubMed:26515425 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Amniotic mesenchymal cells from pre-eclamptic placentae maintain immunomodulatory features as healthy controls.
T1 0-111 Sentence denotes Amniotic mesenchymal cells from pre-eclamptic placentae maintain immunomodulatory features as healthy controls.
T2 112-249 Sentence denotes Pre-eclampsia (PE) is one of the most severe syndromes in human pregnancy, and the underlying mechanisms of PE have yet to be determined.
T2 112-249 Sentence denotes Pre-eclampsia (PE) is one of the most severe syndromes in human pregnancy, and the underlying mechanisms of PE have yet to be determined.
T3 250-434 Sentence denotes Pre-eclampsia is characterized by the alteration of the immune system's activation status, an increase in inflammatory Th1/Th17/APC cells, and a decrease in Th2/Treg subsets/cytokines.
T3 250-434 Sentence denotes Pre-eclampsia is characterized by the alteration of the immune system's activation status, an increase in inflammatory Th1/Th17/APC cells, and a decrease in Th2/Treg subsets/cytokines.
T4 435-639 Sentence denotes Moreover, inflammatory infiltrates have been detected in the amniotic membranes of pre-eclamptic placentae, and to this date limited data are available regarding the role of amniotic membrane cells in PE.
T4 435-639 Sentence denotes Moreover, inflammatory infiltrates have been detected in the amniotic membranes of pre-eclamptic placentae, and to this date limited data are available regarding the role of amniotic membrane cells in PE.
T5 640-844 Sentence denotes Interestingly, we and others have previously shown that human amniotic mesenchymal stromal cells (hAMSC) possess anti-inflammatory properties towards almost all immune cells described to be altered in PE.
T5 640-844 Sentence denotes Interestingly, we and others have previously shown that human amniotic mesenchymal stromal cells (hAMSC) possess anti-inflammatory properties towards almost all immune cells described to be altered in PE.
T6 845-943 Sentence denotes In this study we investigated whether the immunomodulatory properties of hAMSC were altered in PE.
T6 845-943 Sentence denotes In this study we investigated whether the immunomodulatory properties of hAMSC were altered in PE.
T7 944-1174 Sentence denotes We performed a comprehensive study of cell phenotype and investigated the in vitro immunomodulatory properties of hAMSC isolated from pre-eclamptic pregnancies (PE-hAMSC), comparing them to hAMSC from normal pregnancies (N-hAMSC).
T7 944-1174 Sentence denotes We performed a comprehensive study of cell phenotype and investigated the in vitro immunomodulatory properties of hAMSC isolated from pre-eclamptic pregnancies (PE-hAMSC), comparing them to hAMSC from normal pregnancies (N-hAMSC).
T8 1175-1366 Sentence denotes We demonstrate that PE-hAMSC inhibit CD4/CD8 T-cell proliferation, suppress Th1/Th2/Th17 polarization, induce Treg and block dendritic cells and M1 differentiation switching them to M2 cells.
T8 1175-1366 Sentence denotes We demonstrate that PE-hAMSC inhibit CD4/CD8 T-cell proliferation, suppress Th1/Th2/Th17 polarization, induce Treg and block dendritic cells and M1 differentiation switching them to M2 cells.
T9 1367-1610 Sentence denotes Notably, PE-hAMSC generated a more prominent induction of Treg and higher suppression of interferon-γ when compared to N-hAMSC, and this was associated with higher transforming growth factor-β1 secretion and PD-L2/PD-L1 expression in PE-hAMSC.
T9 1367-1610 Sentence denotes Notably, PE-hAMSC generated a more prominent induction of Treg and higher suppression of interferon-γ when compared to N-hAMSC, and this was associated with higher transforming growth factor-β1 secretion and PD-L2/PD-L1 expression in PE-hAMSC.
T10 1611-1743 Sentence denotes In conclusion, for the first time we demonstrate that there is no intrinsic impairment of the immunomodulatory features of PE-hAMSC.
T10 1611-1743 Sentence denotes In conclusion, for the first time we demonstrate that there is no intrinsic impairment of the immunomodulatory features of PE-hAMSC.
T11 1744-1938 Sentence denotes Our results suggest that amniotic mesenchymal stromal cells do not contribute to the disease, but conversely, could participate in offsetting the inflammatory environment which characterizes PE.
T11 1744-1938 Sentence denotes Our results suggest that amniotic mesenchymal stromal cells do not contribute to the disease, but conversely, could participate in offsetting the inflammatory environment which characterizes PE.