> top > projects > Inflammaging > docs > PubMed:26449539 > annotations
Inflammaging  

PubMed:26449539 JSONTXT 27 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes The impact of PPARα activation on whole genome gene expression in human precision cut liver slices.
T1 0-99 Sentence denotes The impact of PPARα activation on whole genome gene expression in human precision cut liver slices.
T2 100-111 Sentence denotes BACKGROUND:
T2 100-111 Sentence denotes BACKGROUND:
T3 112-279 Sentence denotes Studies in mice have shown that PPARα is an important regulator of lipid metabolism in liver and key transcription factor involved in the adaptive response to fasting.
T3 112-279 Sentence denotes Studies in mice have shown that PPARα is an important regulator of lipid metabolism in liver and key transcription factor involved in the adaptive response to fasting.
T4 280-347 Sentence denotes However, much less is known about the role of PPARα in human liver.
T4 280-347 Sentence denotes However, much less is known about the role of PPARα in human liver.
T5 348-356 Sentence denotes METHODS:
T5 348-356 Sentence denotes METHODS:
T6 357-525 Sentence denotes Here we set out to study the function of PPARα in human liver via analysis of whole genome gene regulation in human liver slices treated with the PPARα agonist Wy14643.
T6 357-525 Sentence denotes Here we set out to study the function of PPARα in human liver via analysis of whole genome gene regulation in human liver slices treated with the PPARα agonist Wy14643.
T7 526-534 Sentence denotes RESULTS:
T7 526-534 Sentence denotes RESULTS:
T8 535-745 Sentence denotes Quantitative PCR indicated that PPARα is well expressed in human liver and human liver slices and that the classical PPARα targets PLIN2, VLDLR, ANGPTL4, CPT1A and PDK4 are robustly induced by PPARα activation.
T8 535-745 Sentence denotes Quantitative PCR indicated that PPARα is well expressed in human liver and human liver slices and that the classical PPARα targets PLIN2, VLDLR, ANGPTL4, CPT1A and PDK4 are robustly induced by PPARα activation.
T9 746-883 Sentence denotes Transcriptomics analysis indicated that 617 genes were upregulated and 665 genes were downregulated by PPARα activation (q value < 0.05).
T9 746-883 Sentence denotes Transcriptomics analysis indicated that 617 genes were upregulated and 665 genes were downregulated by PPARα activation (q value < 0.05).
T10 884-1148 Sentence denotes Many genes induced by PPARα activation were involved in lipid metabolism (ACSL5, AGPAT9, FADS1, SLC27A4), xenobiotic metabolism (POR, ABCC2, CYP3A5) or the unfolded protein response, whereas most of the downregulated genes were involved in immune-related pathways.
T10 884-1148 Sentence denotes Many genes induced by PPARα activation were involved in lipid metabolism (ACSL5, AGPAT9, FADS1, SLC27A4), xenobiotic metabolism (POR, ABCC2, CYP3A5) or the unfolded protein response, whereas most of the downregulated genes were involved in immune-related pathways.
T11 1149-1401 Sentence denotes Among the most highly repressed genes upon PPARα activation were several chemokines (e.g. CXCL9-11, CCL8, CX3CL1, CXCL6), interferon γ-induced genes (e.g. IFITM1, IFIT1, IFIT2, IFIT3) and numerous other immune-related genes (e.g. TLR3, NOS2, and LCN2).
T11 1149-1401 Sentence denotes Among the most highly repressed genes upon PPARα activation were several chemokines (e.g. CXCL9-11, CCL8, CX3CL1, CXCL6), interferon γ-induced genes (e.g. IFITM1, IFIT1, IFIT2, IFIT3) and numerous other immune-related genes (e.g. TLR3, NOS2, and LCN2).
T12 1402-1641 Sentence denotes Comparative analysis of gene regulation by Wy14643 between human liver slices and primary human hepatocytes showed that down-regulation of gene expression by PPARα is much better captured by liver slices as compared to primary hepatocytes.
T12 1402-1641 Sentence denotes Comparative analysis of gene regulation by Wy14643 between human liver slices and primary human hepatocytes showed that down-regulation of gene expression by PPARα is much better captured by liver slices as compared to primary hepatocytes.
T13 1642-1783 Sentence denotes In particular, PPARα activation markedly suppressed immunity/inflammation-related genes in human liver slices but not in primary hepatocytes.
T13 1642-1783 Sentence denotes In particular, PPARα activation markedly suppressed immunity/inflammation-related genes in human liver slices but not in primary hepatocytes.
T14 1784-1976 Sentence denotes Finally, several putative new target genes of PPARα were identified that were commonly induced by PPARα activation in the two human liver model systems, including TSKU, RHOF, CA12 and VSIG10L.
T14 1784-1976 Sentence denotes Finally, several putative new target genes of PPARα were identified that were commonly induced by PPARα activation in the two human liver model systems, including TSKU, RHOF, CA12 and VSIG10L.
T15 1977-1988 Sentence denotes CONCLUSION:
T15 1977-1988 Sentence denotes CONCLUSION:
T16 1989-2148 Sentence denotes Our paper demonstrates the suitability and superiority of human liver slices over primary hepatocytes for studying the functional role of PPARα in human liver.
T16 1989-2148 Sentence denotes Our paper demonstrates the suitability and superiority of human liver slices over primary hepatocytes for studying the functional role of PPARα in human liver.
T17 2149-2435 Sentence denotes Our data underscore the major role of PPARα in regulation of hepatic lipid and xenobiotic metabolism in human liver and reveal a marked immuno-suppressive/anti-inflammatory effect of PPARα in human liver slices that may be therapeutically relevant for non-alcoholic fatty liver disease.
T17 2149-2435 Sentence denotes Our data underscore the major role of PPARα in regulation of hepatic lipid and xenobiotic metabolism in human liver and reveal a marked immuno-suppressive/anti-inflammatory effect of PPARα in human liver slices that may be therapeutically relevant for non-alcoholic fatty liver disease.