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PubMed:26218277 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Arg25Pro (c.915G>C) polymorphism of transforming growth factor β1 gene suggests an association with increased risk for Hashimoto's thyroiditis.
T1 0-143 Sentence denotes Arg25Pro (c.915G>C) polymorphism of transforming growth factor β1 gene suggests an association with increased risk for Hashimoto's thyroiditis.
T2 144-155 Sentence denotes BACKGROUND:
T2 144-155 Sentence denotes BACKGROUND:
T3 156-391 Sentence denotes The etiopathogenesis of Hashimoto's thyroiditis (HT) - has not been clearly elucidated although the role of chronic inflammation, endothelial dysfunction, and imbalance between pro- and anti-inflammatory cytokines has been established.
T3 156-391 Sentence denotes The etiopathogenesis of Hashimoto's thyroiditis (HT) - has not been clearly elucidated although the role of chronic inflammation, endothelial dysfunction, and imbalance between pro- and anti-inflammatory cytokines has been established.
T4 392-600 Sentence denotes Transforming growth factor β1 (TGFβ1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, production of autoantibodies and thyrocyte destruction seen in patients with HT.
T4 392-600 Sentence denotes Transforming growth factor β1 (TGFβ1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, production of autoantibodies and thyrocyte destruction seen in patients with HT.
T5 601-605 Sentence denotes AIM:
T5 601-605 Sentence denotes AIM:
T6 606-805 Sentence denotes The aim of the present study was to investigate the possible association of Leu10Pro (c.869T>C) and Arg25Pro (c.915G>C) single nucleotide polymorphisms (SNPs) of TGFβ1 gene with the occurrence of HT.
T6 606-805 Sentence denotes The aim of the present study was to investigate the possible association of Leu10Pro (c.869T>C) and Arg25Pro (c.915G>C) single nucleotide polymorphisms (SNPs) of TGFβ1 gene with the occurrence of HT.
T7 806-814 Sentence denotes METHODS:
T7 806-814 Sentence denotes METHODS:
T8 815-1034 Sentence denotes We analyzed the genotype and allele frequencies of polymorphisms at codon 10 and 25 in 178 patients who had been diagnosed as having HT and 197 healthy controls using PCR-restriction fragment length polymorphism (RFLP).
T8 815-1034 Sentence denotes We analyzed the genotype and allele frequencies of polymorphisms at codon 10 and 25 in 178 patients who had been diagnosed as having HT and 197 healthy controls using PCR-restriction fragment length polymorphism (RFLP).
T9 1035-1043 Sentence denotes RESULTS:
T9 1035-1043 Sentence denotes RESULTS:
T10 1044-1137 Sentence denotes There was no notable risk for HT afflicted by Leu10Pro (c.869T>C) polymorphism of TGFβ1 gene.
T10 1044-1137 Sentence denotes There was no notable risk for HT afflicted by Leu10Pro (c.869T>C) polymorphism of TGFβ1 gene.
T11 1138-1310 Sentence denotes However, there was a significant increase of Arg25Pro (c.915G>C) C allele frequency in patients with HT compared with healthy controls (p=0.003, OR=1.87, 95% CI=1.23-2.84).
T11 1138-1310 Sentence denotes However, there was a significant increase of Arg25Pro (c.915G>C) C allele frequency in patients with HT compared with healthy controls (p=0.003, OR=1.87, 95% CI=1.23-2.84).
T12 1311-1463 Sentence denotes Moreover, heterozygous (CG) subjects had a 2.53-fold increased risk for developing HT with respect to wild (GG) homozygotes (p<0.001, 95% CI=1.57-4.05).
T12 1311-1463 Sentence denotes Moreover, heterozygous (CG) subjects had a 2.53-fold increased risk for developing HT with respect to wild (GG) homozygotes (p<0.001, 95% CI=1.57-4.05).
T13 1464-1564 Sentence denotes TSH levels in CG heterozygous patients were increased in comparison with wild homozygotes (p=0.006).
T13 1464-1564 Sentence denotes TSH levels in CG heterozygous patients were increased in comparison with wild homozygotes (p=0.006).
T14 1565-1576 Sentence denotes CONCLUSION:
T14 1565-1576 Sentence denotes CONCLUSION:
T15 1577-1694 Sentence denotes This study indicates that the Arg25Pro (c.915G>C) polymorphism of TGFβ1 gene may be related to increased risk for HT.
T15 1577-1694 Sentence denotes This study indicates that the Arg25Pro (c.915G>C) polymorphism of TGFβ1 gene may be related to increased risk for HT.