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PubMed:26115698 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-63 Sentence denotes MAFB as a novel regulator of human adipose tissue inflammation.
T1 0-63 Sentence denotes MAFB as a novel regulator of human adipose tissue inflammation.
T2 64-80 Sentence denotes AIMS/HYPOTHESIS:
T2 64-80 Sentence denotes AIMS/HYPOTHESIS:
T3 81-226 Sentence denotes Dysregulated expression of metabolic and inflammatory genes is a prominent consequence of obesity causing insulin resistance and type 2 diabetes.
T3 81-226 Sentence denotes Dysregulated expression of metabolic and inflammatory genes is a prominent consequence of obesity causing insulin resistance and type 2 diabetes.
T4 227-356 Sentence denotes Finding causative factors is essential to understanding progression of these pathologies and discovering new therapeutic targets.
T4 227-356 Sentence denotes Finding causative factors is essential to understanding progression of these pathologies and discovering new therapeutic targets.
T5 357-504 Sentence denotes The transcription factor V-maf musculoaponeurotic fibrosarcoma oncogene homologue B (MAFB) is highly expressed in human white adipose tissue (WAT).
T5 357-504 Sentence denotes The transcription factor V-maf musculoaponeurotic fibrosarcoma oncogene homologue B (MAFB) is highly expressed in human white adipose tissue (WAT).
T6 505-568 Sentence denotes However, its role in the regulation of WAT function is elusive.
T6 505-568 Sentence denotes However, its role in the regulation of WAT function is elusive.
T7 569-685 Sentence denotes We aimed to characterise MAFB expression and function in human WAT in the context of obesity and insulin resistance.
T7 569-685 Sentence denotes We aimed to characterise MAFB expression and function in human WAT in the context of obesity and insulin resistance.
T8 686-830 Sentence denotes METHODS: MAFB mRNA expression was evaluated in human WAT from seven cohorts with large inter-individual variation in BMI and metabolic features.
T8 686-830 Sentence denotes METHODS: MAFB mRNA expression was evaluated in human WAT from seven cohorts with large inter-individual variation in BMI and metabolic features.
T9 831-933 Sentence denotes Insulin-induced adipocyte lipogenesis and lipolysis were measured and correlated with MAFB expression.
T9 831-933 Sentence denotes Insulin-induced adipocyte lipogenesis and lipolysis were measured and correlated with MAFB expression.
T10 934-1043 Sentence denotes MAFB regulation during adipogenesis and the effects of MAFB suppression in human adipocytes was investigated.
T10 934-1043 Sentence denotes MAFB regulation during adipogenesis and the effects of MAFB suppression in human adipocytes was investigated.
T11 1044-1142 Sentence denotes MAFB regulation by TNF-α was examined in human primary adipocytes and THP-1 monocytes/macrophages.
T11 1044-1142 Sentence denotes MAFB regulation by TNF-α was examined in human primary adipocytes and THP-1 monocytes/macrophages.
T12 1143-1329 Sentence denotes RESULTS: MAFB expression in human adipocytes is upregulated during adipogenesis, increases with BMI in WAT, correlates with adverse metabolic features and is decreased after weight loss.
T12 1143-1329 Sentence denotes RESULTS: MAFB expression in human adipocytes is upregulated during adipogenesis, increases with BMI in WAT, correlates with adverse metabolic features and is decreased after weight loss.
T13 1330-1440 Sentence denotes MAFB downregulation decreases proinflammatory gene expression in adipocytes and interferes with TNF-α effects.
T13 1330-1440 Sentence denotes MAFB downregulation decreases proinflammatory gene expression in adipocytes and interferes with TNF-α effects.
T14 1441-1555 Sentence denotes Interestingly, MAFB is differentially regulated by TNF-α in adipocytes (suppressed) and THP-1 cells (upregulated).
T14 1441-1555 Sentence denotes Interestingly, MAFB is differentially regulated by TNF-α in adipocytes (suppressed) and THP-1 cells (upregulated).
T15 1556-1693 Sentence denotes Further, MAFB is primarily expressed in WAT macrophages/monocytes and its expression correlates with macrophage and inflammatory markers.
T15 1556-1693 Sentence denotes Further, MAFB is primarily expressed in WAT macrophages/monocytes and its expression correlates with macrophage and inflammatory markers.
T16 1694-1721 Sentence denotes CONCLUSIONS/INTERPRETATION:
T16 1694-1721 Sentence denotes CONCLUSIONS/INTERPRETATION:
T17 1722-1868 Sentence denotes Our findings indicate that MAFB is a regulator and a marker of adipose tissue inflammation, a process that subsequently causes insulin resistance.
T17 1722-1868 Sentence denotes Our findings indicate that MAFB is a regulator and a marker of adipose tissue inflammation, a process that subsequently causes insulin resistance.