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Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation.
T1 0-113 Sentence denotes Structural glycobiology of human α1-acid glycoprotein and its implications for pharmacokinetics and inflammation.
T2 114-233 Sentence denotes Human α1-acid glycoprotein (AGP) is an abundant human plasma glycoprotein that may be N-glycosylated at five positions.
T2 114-233 Sentence denotes Human α1-acid glycoprotein (AGP) is an abundant human plasma glycoprotein that may be N-glycosylated at five positions.
T3 234-329 Sentence denotes AGP plays important roles on pharmacokinetics and can rise up to 5-fold in inflammatory events.
T3 234-329 Sentence denotes AGP plays important roles on pharmacokinetics and can rise up to 5-fold in inflammatory events.
T4 330-460 Sentence denotes In such events, the glycan chains attached to Asn54, Asn75 and Asn85 may become fucosylated, originating a sialyl-Lewis X epitope.
T4 330-460 Sentence denotes In such events, the glycan chains attached to Asn54, Asn75 and Asn85 may become fucosylated, originating a sialyl-Lewis X epitope.
T5 461-511 Sentence denotes This epitope, in turn, can bind selectin proteins.
T5 461-511 Sentence denotes This epitope, in turn, can bind selectin proteins.
T6 512-561 Sentence denotes Such interplay is important for immunomodulation.
T6 512-561 Sentence denotes Such interplay is important for immunomodulation.
T7 562-766 Sentence denotes While the X-ray structure of unglycosylated AGP has been reported, the absence of the glycan chains hampered the further insights into its structural biology and, ultimately, into its biological function.
T7 562-766 Sentence denotes While the X-ray structure of unglycosylated AGP has been reported, the absence of the glycan chains hampered the further insights into its structural biology and, ultimately, into its biological function.
T8 767-1018 Sentence denotes Thus, the current work intends to contribute in the characterization of the structural glycobiology and function of AGP by building a structural model of its fully glycosylated form, taking into account the different glycoforms that are found in vivo.
T8 767-1018 Sentence denotes Thus, the current work intends to contribute in the characterization of the structural glycobiology and function of AGP by building a structural model of its fully glycosylated form, taking into account the different glycoforms that are found in vivo.
T9 1019-1174 Sentence denotes The obtained data points to the absence of a major influence of glycosylation on AGP's secondary structure, in agreement with crystallography observations.
T9 1019-1174 Sentence denotes The obtained data points to the absence of a major influence of glycosylation on AGP's secondary structure, in agreement with crystallography observations.
T10 1175-1377 Sentence denotes However, the glycan chains seem able to interfere with the protein dynamics, mainly at the AGP-ligand-binding site, indicating a possible role in its complexation to drugs and other bioactive compounds.
T10 1175-1377 Sentence denotes However, the glycan chains seem able to interfere with the protein dynamics, mainly at the AGP-ligand-binding site, indicating a possible role in its complexation to drugs and other bioactive compounds.
T11 1378-1631 Sentence denotes By examining the influence of fucosylation on AGP structure and binding to selectins, it is proposed that the latter may bind to glycan chains linked to Asn54 and Asn75, and that this binding may involve other glycans, such as the one attached to Asn15.
T11 1378-1631 Sentence denotes By examining the influence of fucosylation on AGP structure and binding to selectins, it is proposed that the latter may bind to glycan chains linked to Asn54 and Asn75, and that this binding may involve other glycans, such as the one attached to Asn15.
T12 1632-1762 Sentence denotes These results point to an increased participation of carbohydrates on the observed AGP roles in pharmacokinetics and inflammation.
T12 1632-1762 Sentence denotes These results point to an increased participation of carbohydrates on the observed AGP roles in pharmacokinetics and inflammation.