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PubMed:25746000 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-105 Sentence denotes MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription.
T1 0-105 Sentence denotes MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription.
T2 106-255 Sentence denotes Malignant tumors are exemplified by excessive proliferation and aggressive migration/invasion contributing to increased mortality of cancer patients.
T2 106-255 Sentence denotes Malignant tumors are exemplified by excessive proliferation and aggressive migration/invasion contributing to increased mortality of cancer patients.
T3 256-354 Sentence denotes Matrix metalloproteinase 9 (MMP9) expression is positively correlated with lung cancer malignancy.
T3 256-354 Sentence denotes Matrix metalloproteinase 9 (MMP9) expression is positively correlated with lung cancer malignancy.
T4 355-431 Sentence denotes The mechanism underlying an elevated MMP9 expression is not clearly defined.
T4 355-431 Sentence denotes The mechanism underlying an elevated MMP9 expression is not clearly defined.
T5 432-653 Sentence denotes We demonstrate here that the transcriptional modulator megakaryocytic leukemia 1 (MKL1) was activated by hypoxia and transforming growth factor (TGF-β), two prominent pro-malignancy factors, in cultured lung cancer cells.
T5 432-653 Sentence denotes We demonstrate here that the transcriptional modulator megakaryocytic leukemia 1 (MKL1) was activated by hypoxia and transforming growth factor (TGF-β), two prominent pro-malignancy factors, in cultured lung cancer cells.
T6 654-734 Sentence denotes MKL1 levels were also increased in more invasive types of lung cancer in humans.
T6 654-734 Sentence denotes MKL1 levels were also increased in more invasive types of lung cancer in humans.
T7 735-834 Sentence denotes Depletion of MKL1 in lung cancer cells attenuated migration and invasion both in vitro and in vivo.
T7 735-834 Sentence denotes Depletion of MKL1 in lung cancer cells attenuated migration and invasion both in vitro and in vivo.
T8 835-978 Sentence denotes Overexpression of MKL1 potentiated the induction of MMP9 transcription by hypoxia and TGF-β, whereas MKL1 silencing diminished MMP9 expression.
T8 835-978 Sentence denotes Overexpression of MKL1 potentiated the induction of MMP9 transcription by hypoxia and TGF-β, whereas MKL1 silencing diminished MMP9 expression.
T9 979-1073 Sentence denotes Of interest, MKL1 knockdown eliminated histone H3K4 methylation surrounding the MMP9 promoter.
T9 979-1073 Sentence denotes Of interest, MKL1 knockdown eliminated histone H3K4 methylation surrounding the MMP9 promoter.
T10 1074-1208 Sentence denotes Further analyses revealed that MKL1 recruited ASH2, a component of the H3K4 methyltransferase complex, to activate MMP9 transcription.
T10 1074-1208 Sentence denotes Further analyses revealed that MKL1 recruited ASH2, a component of the H3K4 methyltransferase complex, to activate MMP9 transcription.
T11 1209-1302 Sentence denotes Depletion of ASH2 ameliorated cancer cell migration and invasion in an MMP9-dependent manner.
T11 1209-1302 Sentence denotes Depletion of ASH2 ameliorated cancer cell migration and invasion in an MMP9-dependent manner.
T12 1303-1440 Sentence denotes Together our data indicate that MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription.
T12 1303-1440 Sentence denotes Together our data indicate that MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription.