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PubMed:25669997 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders.
T1 0-102 Sentence denotes Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders.
T2 103-245 Sentence denotes Rett syndrome is a neurodevelopmental disorder, which occurs in about 1:15,000 females and presents with neurologic and communication defects.
T2 103-245 Sentence denotes Rett syndrome is a neurodevelopmental disorder, which occurs in about 1:15,000 females and presents with neurologic and communication defects.
T3 246-478 Sentence denotes It is transmitted as an X-linked dominant linked to mutations of the methyl-CpG-binding protein (MeCP2), a gene transcription suppressor, but its definitive pathogenesis is unknown thus hindering development of effective treatments.
T3 246-478 Sentence denotes It is transmitted as an X-linked dominant linked to mutations of the methyl-CpG-binding protein (MeCP2), a gene transcription suppressor, but its definitive pathogenesis is unknown thus hindering development of effective treatments.
T4 479-610 Sentence denotes Almost half of children with Rett syndrome also have behavioral symptoms consistent with those of autism spectrum disorders (ASDs).
T4 479-610 Sentence denotes Almost half of children with Rett syndrome also have behavioral symptoms consistent with those of autism spectrum disorders (ASDs).
T5 611-913 Sentence denotes PubMed was searched (2005-2014) using the terms: allergy, atopy, brain, brain-derived neurotrophic factor (BDNF), corticotropin-releasing hormone (CRH), cytokines, gene mutations, inflammation, mast cells (MCs), microglia, mitochondria, neurotensin (NT), neurotrophins, seizures, stress, and treatment.
T5 611-913 Sentence denotes PubMed was searched (2005-2014) using the terms: allergy, atopy, brain, brain-derived neurotrophic factor (BDNF), corticotropin-releasing hormone (CRH), cytokines, gene mutations, inflammation, mast cells (MCs), microglia, mitochondria, neurotensin (NT), neurotrophins, seizures, stress, and treatment.
T6 914-1007 Sentence denotes There are a number of intriguing differences and similarities between Rett syndrome and ASDs.
T6 914-1007 Sentence denotes There are a number of intriguing differences and similarities between Rett syndrome and ASDs.
T7 1008-1128 Sentence denotes Rett syndrome occurs in females, while ASDs more often in males, and the former has neurologic disabilities unlike ASDs.
T7 1008-1128 Sentence denotes Rett syndrome occurs in females, while ASDs more often in males, and the former has neurologic disabilities unlike ASDs.
T8 1129-1210 Sentence denotes There is evidence of dysregulated immune system early in life in both conditions.
T8 1129-1210 Sentence denotes There is evidence of dysregulated immune system early in life in both conditions.
T9 1211-1425 Sentence denotes Lack of microglial phagocytosis and decreased levels of BDNF appear to distinguish Rett syndrome from ASDs, in which there is instead microglia activation and/or proliferation and possibly defective BDNF signaling.
T9 1211-1425 Sentence denotes Lack of microglial phagocytosis and decreased levels of BDNF appear to distinguish Rett syndrome from ASDs, in which there is instead microglia activation and/or proliferation and possibly defective BDNF signaling.
T10 1426-1540 Sentence denotes Moreover, brain mast cell (MC) activation and focal inflammation may be more prominent in ASDs than Rett syndrome.
T10 1426-1540 Sentence denotes Moreover, brain mast cell (MC) activation and focal inflammation may be more prominent in ASDs than Rett syndrome.
T11 1541-1722 Sentence denotes The flavonoid luteolin blocks microglia and MC activation, provides BDNF-like activity, reverses Rett phenotype in mouse models, and has a significant benefit in children with ASDs.
T11 1541-1722 Sentence denotes The flavonoid luteolin blocks microglia and MC activation, provides BDNF-like activity, reverses Rett phenotype in mouse models, and has a significant benefit in children with ASDs.
T12 1723-1835 Sentence denotes Appropriate formulations of luteolin or other natural molecules may be useful in the treatment of Rett syndrome.
T12 1723-1835 Sentence denotes Appropriate formulations of luteolin or other natural molecules may be useful in the treatment of Rett syndrome.