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PubMed:25515248 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes Chondroprotective potential of Phyllanthus amarus Schum. & Thonn. in experimentally induced cartilage degradation in the explants culture model.
T1 0-144 Sentence denotes Chondroprotective potential of Phyllanthus amarus Schum. & Thonn. in experimentally induced cartilage degradation in the explants culture model.
T2 145-343 Sentence denotes Phyllanthus amarus Schum. & Thonn. (P. amarus) has been reported to exhibit anti-inflammation and antiarthritis properties leading to our interest to examine its beneficial effect in osteoarthritis.
T2 145-343 Sentence denotes Phyllanthus amarus Schum. & Thonn. (P. amarus) has been reported to exhibit anti-inflammation and antiarthritis properties leading to our interest to examine its beneficial effect in osteoarthritis.
T3 344-524 Sentence denotes Thus, this study aimed to explore the chondroprotective potential of P. amarus extract (PAE) and its major compounds, phyllanthin and hypophyllanthin, in a cartilage explant model.
T3 344-524 Sentence denotes Thus, this study aimed to explore the chondroprotective potential of P. amarus extract (PAE) and its major compounds, phyllanthin and hypophyllanthin, in a cartilage explant model.
T4 525-708 Sentence denotes Various concentrations of P. amarus extract, phyllanthin and hypophyllanthin, were treated on porcine articular cartilage explants induced with 25 ng/ml of interleukin-1 beta (IL-1β).
T4 525-708 Sentence denotes Various concentrations of P. amarus extract, phyllanthin and hypophyllanthin, were treated on porcine articular cartilage explants induced with 25 ng/ml of interleukin-1 beta (IL-1β).
T5 709-923 Sentence denotes After 4 days of incubation, the culture medium was measured for the release of sulfate glycosaminoglycans (s-GAGs) and matrix metalloproteinase-2 (MMP-2) activity by DMMB binding assay and zymography, respectively.
T5 709-923 Sentence denotes After 4 days of incubation, the culture medium was measured for the release of sulfate glycosaminoglycans (s-GAGs) and matrix metalloproteinase-2 (MMP-2) activity by DMMB binding assay and zymography, respectively.
T6 924-1091 Sentence denotes The explant tissues were analyzed for the remaining of uronic acid content by colorimetric assay and stained with safranin-O for investigation of proteoglycan content.
T6 924-1091 Sentence denotes The explant tissues were analyzed for the remaining of uronic acid content by colorimetric assay and stained with safranin-O for investigation of proteoglycan content.
T7 1092-1172 Sentence denotes Cell viability of this model was evaluated by lactate dehydrogenase (LDH) assay.
T7 1092-1172 Sentence denotes Cell viability of this model was evaluated by lactate dehydrogenase (LDH) assay.
T8 1173-1488 Sentence denotes Chondroprotective potential of PAE and the major components against IL-1β-induced cartilage explant degradation were revealed by the decreased s-GAGs level and MMP-2 activity in culture medium consistent with an increase in uronic acid and proteoglycan contents in the explants when compared to the IL-1β treatment.
T8 1173-1488 Sentence denotes Chondroprotective potential of PAE and the major components against IL-1β-induced cartilage explant degradation were revealed by the decreased s-GAGs level and MMP-2 activity in culture medium consistent with an increase in uronic acid and proteoglycan contents in the explants when compared to the IL-1β treatment.
T9 1489-1578 Sentence denotes These results agreed with those of diacerein and sesamin which used as positive controls.
T9 1489-1578 Sentence denotes These results agreed with those of diacerein and sesamin which used as positive controls.
T10 1579-1723 Sentence denotes In addition, better chondroprotective activities of P. amarus crude extracts than those of the purified components were disclosed in this study.
T10 1579-1723 Sentence denotes In addition, better chondroprotective activities of P. amarus crude extracts than those of the purified components were disclosed in this study.
T11 1724-1888 Sentence denotes Hence, this is a pioneering study presenting the chondroprotective potential of PAE which may augment its application for therapeutic use as an antiarthritic agent.
T11 1724-1888 Sentence denotes Hence, this is a pioneering study presenting the chondroprotective potential of PAE which may augment its application for therapeutic use as an antiarthritic agent.