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PubMed:25372662 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1 0-121 Sentence denotes Identification of novel single nucleotide polymorphisms associated with acute respiratory distress syndrome by exome-seq.
T1 0-121 Sentence denotes Identification of novel single nucleotide polymorphisms associated with acute respiratory distress syndrome by exome-seq.
T2 122-333 Sentence denotes Acute respiratory distress syndrome (ARDS) is a lung condition characterized by impaired gas exchange with systemic release of inflammatory mediators, causing pulmonary inflammation, vascular leak and hypoxemia.
T2 122-333 Sentence denotes Acute respiratory distress syndrome (ARDS) is a lung condition characterized by impaired gas exchange with systemic release of inflammatory mediators, causing pulmonary inflammation, vascular leak and hypoxemia.
T3 334-419 Sentence denotes Existing biomarkers have limited effectiveness as diagnostic and therapeutic targets.
T3 334-419 Sentence denotes Existing biomarkers have limited effectiveness as diagnostic and therapeutic targets.
T4 420-562 Sentence denotes To identify disease-associating variants in ARDS patients, whole-exome sequencing was performed on 96 ARDS patients, detecting 1,382,399 SNPs.
T4 420-562 Sentence denotes To identify disease-associating variants in ARDS patients, whole-exome sequencing was performed on 96 ARDS patients, detecting 1,382,399 SNPs.
T5 563-738 Sentence denotes By comparing these exome data to those of the 1000 Genomes Project, we identified a number of single nucleotide polymorphisms (SNP) which are potentially associated with ARDS.
T5 563-738 Sentence denotes By comparing these exome data to those of the 1000 Genomes Project, we identified a number of single nucleotide polymorphisms (SNP) which are potentially associated with ARDS.
T6 739-849 Sentence denotes 50,190SNPs were found in all case subgroups and controls, of which89 SNPs were associated with susceptibility.
T6 739-849 Sentence denotes 50,190SNPs were found in all case subgroups and controls, of which89 SNPs were associated with susceptibility.
T7 850-1590 Sentence denotes We validated three SNPs (rs78142040, rs9605146 and rs3848719) in additional ARDS patients to substantiate their associations with susceptibility, severity and outcome of ARDS. rs78142040 (C>T) occurs within a histone mark (intron 6) of the Arylsulfatase D gene. rs9605146 (G>A) causes a deleterious coding change (proline to leucine) in the XK, Kell blood group complex subunit-related family, member 3 gene. rs3848719 (G>A) is a synonymous SNP in the Zinc-Finger/Leucine-Zipper Co-Transducer NIF1 gene. rs78142040, rs9605146, and rs3848719 are associated significantly with susceptibility to ARDS. rs3848719 is associated with APACHE II score quartile. rs78142040 is associated with 60-day mortality in the overall ARDS patient population.
T7 850-1590 Sentence denotes We validated three SNPs (rs78142040, rs9605146 and rs3848719) in additional ARDS patients to substantiate their associations with susceptibility, severity and outcome of ARDS. rs78142040 (C>T) occurs within a histone mark (intron 6) of the Arylsulfatase D gene. rs9605146 (G>A) causes a deleterious coding change (proline to leucine) in the XK, Kell blood group complex subunit-related family, member 3 gene. rs3848719 (G>A) is a synonymous SNP in the Zinc-Finger/Leucine-Zipper Co-Transducer NIF1 gene. rs78142040, rs9605146, and rs3848719 are associated significantly with susceptibility to ARDS. rs3848719 is associated with APACHE II score quartile. rs78142040 is associated with 60-day mortality in the overall ARDS patient population.
T8 1591-1666 Sentence denotes Exome-seq is a powerful tool to identify potential new biomarkers for ARDS.
T8 1591-1666 Sentence denotes Exome-seq is a powerful tool to identify potential new biomarkers for ARDS.
T9 1667-1811 Sentence denotes We selectively validated three SNPs which have not been previously associated with ARDS and represent potential new genetic biomarkers for ARDS.
T9 1667-1811 Sentence denotes We selectively validated three SNPs which have not been previously associated with ARDS and represent potential new genetic biomarkers for ARDS.
T10 1812-1937 Sentence denotes Additional validation in larger patient populations and further exploration of underlying molecular mechanisms are warranted.
T10 1812-1937 Sentence denotes Additional validation in larger patient populations and further exploration of underlying molecular mechanisms are warranted.