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PubMed:25370155 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes Probiotics prevent Hirschsprung's disease-associated enterocolitis: a prospective multicenter randomized controlled trial.
T1 0-122 Sentence denotes Probiotics prevent Hirschsprung's disease-associated enterocolitis: a prospective multicenter randomized controlled trial.
T2 123-134 Sentence denotes BACKGROUND:
T2 123-134 Sentence denotes BACKGROUND:
T3 135-243 Sentence denotes Enterocolitis (EC) is the most common and serious postoperative complication of Hirschsprung's disease (HD).
T3 135-243 Sentence denotes Enterocolitis (EC) is the most common and serious postoperative complication of Hirschsprung's disease (HD).
T4 244-334 Sentence denotes Probiotics potentially play a protective role in maintaining intestinal mucosal integrity.
T4 244-334 Sentence denotes Probiotics potentially play a protective role in maintaining intestinal mucosal integrity.
T5 335-519 Sentence denotes Based on the beneficial effects of probiotics, we hypothesized that oral probiotics could decrease the incidence and severity of Hirschsprung's disease-associated enterocolitis (HAEC).
T5 335-519 Sentence denotes Based on the beneficial effects of probiotics, we hypothesized that oral probiotics could decrease the incidence and severity of Hirschsprung's disease-associated enterocolitis (HAEC).
T6 520-528 Sentence denotes METHODS:
T6 520-528 Sentence denotes METHODS:
T7 529-687 Sentence denotes We conducted a prospective, multicenter, randomized, and controlled trial to assess whether oral probiotics could decrease the incidence and severity of HAEC.
T7 529-687 Sentence denotes We conducted a prospective, multicenter, randomized, and controlled trial to assess whether oral probiotics could decrease the incidence and severity of HAEC.
T8 688-774 Sentence denotes HD patients were randomly assigned into the control group and probiotic-treated group.
T8 688-774 Sentence denotes HD patients were randomly assigned into the control group and probiotic-treated group.
T9 775-860 Sentence denotes All children in probiotic-treated group were fed with probiotics per day for 4 weeks.
T9 775-860 Sentence denotes All children in probiotic-treated group were fed with probiotics per day for 4 weeks.
T10 861-928 Sentence denotes In next 3 months, the incidence and severity of HAEC were analyzed.
T10 861-928 Sentence denotes In next 3 months, the incidence and severity of HAEC were analyzed.
T11 929-1088 Sentence denotes The peripheral blood T lymphocyte subsets and cytokines, including TNF-α, IFN-γ, IL-6, and IL-10, were analyzed by flow cytometry and enzyme immunoassay (EIA).
T11 929-1088 Sentence denotes The peripheral blood T lymphocyte subsets and cytokines, including TNF-α, IFN-γ, IL-6, and IL-10, were analyzed by flow cytometry and enzyme immunoassay (EIA).
T12 1089-1097 Sentence denotes RESULTS:
T12 1089-1097 Sentence denotes RESULTS:
T13 1098-1213 Sentence denotes Compared with the control group, the incidence of HAEC in the probiotic-treated group was significantly diminished.
T13 1098-1213 Sentence denotes Compared with the control group, the incidence of HAEC in the probiotic-treated group was significantly diminished.
T14 1214-1263 Sentence denotes The severity of EC was also remarkably decreased.
T14 1214-1263 Sentence denotes The severity of EC was also remarkably decreased.
T15 1264-1318 Sentence denotes Furthermore, probiotics balanced T lymphocyte subsets.
T15 1264-1318 Sentence denotes Furthermore, probiotics balanced T lymphocyte subsets.
T16 1319-1494 Sentence denotes Moreover, pro-inflammatory cytokines TNF-α, IFN-γ, and IL-6 were significantly decreased and anti-inflammatory cytokine IL-10 was notably increased in probiotic-treated group.
T16 1319-1494 Sentence denotes Moreover, pro-inflammatory cytokines TNF-α, IFN-γ, and IL-6 were significantly decreased and anti-inflammatory cytokine IL-10 was notably increased in probiotic-treated group.
T17 1495-1507 Sentence denotes CONCLUSIONS:
T17 1495-1507 Sentence denotes CONCLUSIONS:
T18 1508-1607 Sentence denotes Probiotics not only significantly diminished the incidence but also decreased the severity of HAEC.
T18 1508-1607 Sentence denotes Probiotics not only significantly diminished the incidence but also decreased the severity of HAEC.
T19 1608-1831 Sentence denotes Moreover, our study revealed that probiotics decreased pro-inflammatory cytokine and increased anti-inflammatory cytokine and furthermore balanced T lymphocytes (registered with ClinicalTrials.gov, NCT number: NCT01934959).
T19 1608-1831 Sentence denotes Moreover, our study revealed that probiotics decreased pro-inflammatory cytokine and increased anti-inflammatory cytokine and furthermore balanced T lymphocytes (registered with ClinicalTrials.gov, NCT number: NCT01934959).