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PubMed:25361765 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7.
T1 0-96 Sentence denotes Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7.
T2 97-314 Sentence denotes Although ischemic stroke is a major cause of death and disability worldwide, only a small fraction of patients benefit from the current thrombolytic therapy due to a risk of cerebral hemorrhage caused by inflammation.
T2 97-314 Sentence denotes Although ischemic stroke is a major cause of death and disability worldwide, only a small fraction of patients benefit from the current thrombolytic therapy due to a risk of cerebral hemorrhage caused by inflammation.
T3 315-418 Sentence denotes Thus, the development of a new strategy to combat inflammation during thrombolysis is an urgent demand.
T3 315-418 Sentence denotes Thus, the development of a new strategy to combat inflammation during thrombolysis is an urgent demand.
T4 419-552 Sentence denotes The small molecule thrombolytic SMTP-7 effectively treats ischemic stroke in several animal models with reducing cerebral hemorrhage.
T4 419-552 Sentence denotes The small molecule thrombolytic SMTP-7 effectively treats ischemic stroke in several animal models with reducing cerebral hemorrhage.
T5 553-648 Sentence denotes Here we revealed that SMTP-7 targeted soluble epoxide hydrolase (sEH) to suppress inflammation.
T5 553-648 Sentence denotes Here we revealed that SMTP-7 targeted soluble epoxide hydrolase (sEH) to suppress inflammation.
T6 649-811 Sentence denotes SMTP-7 inhibited both of the two sEH enzyme activities: epoxide hydrolase (which inactivates anti-inflammatory epoxy-fatty acids) and lipid phosphate phosphatase.
T6 649-811 Sentence denotes SMTP-7 inhibited both of the two sEH enzyme activities: epoxide hydrolase (which inactivates anti-inflammatory epoxy-fatty acids) and lipid phosphate phosphatase.
T7 812-951 Sentence denotes SMTP-7 suppressed epoxy-fatty acid hydrolysis in HepG2 cells in culture, implicating the sEH inhibition in the anti-inflammatory mechanism.
T7 812-951 Sentence denotes SMTP-7 suppressed epoxy-fatty acid hydrolysis in HepG2 cells in culture, implicating the sEH inhibition in the anti-inflammatory mechanism.
T8 952-1026 Sentence denotes The sEH inhibition by SMTP-7 was independent of its thrombolytic activity.
T8 952-1026 Sentence denotes The sEH inhibition by SMTP-7 was independent of its thrombolytic activity.
T9 1027-1167 Sentence denotes The simultaneous targeting of thrombolysis and sEH by a single molecule is a promising strategy to revolutionize the current stroke therapy.
T9 1027-1167 Sentence denotes The simultaneous targeting of thrombolysis and sEH by a single molecule is a promising strategy to revolutionize the current stroke therapy.