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PubMed:25315623 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T1 0-43 Sentence denotes Potassium ion channels and allergic asthma.
T1 0-43 Sentence denotes Potassium ion channels and allergic asthma.
T2 44-257 Sentence denotes High-conductive calcium-sensitive potassium channels (BK+Ca) and ATP-sensitive potassium (K+ATP) channels play a significant role in the airway smooth muscle cell and goblet cell function, and cytokine production.
T2 44-257 Sentence denotes High-conductive calcium-sensitive potassium channels (BK+Ca) and ATP-sensitive potassium (K+ATP) channels play a significant role in the airway smooth muscle cell and goblet cell function, and cytokine production.
T3 258-427 Sentence denotes The present study evaluated the therapeutic potential of BK+Ca and K+ATP openers, NS 1619 and pinacidil, respectively, in an experimental model of allergic inflammation.
T3 258-427 Sentence denotes The present study evaluated the therapeutic potential of BK+Ca and K+ATP openers, NS 1619 and pinacidil, respectively, in an experimental model of allergic inflammation.
T4 428-586 Sentence denotes Airway allergic inflammation was induced with ovalbumine in guinea pigs during 21 days, which was followed by a 14-day treatment with BK+Ca and K+ATP openers.
T4 428-586 Sentence denotes Airway allergic inflammation was induced with ovalbumine in guinea pigs during 21 days, which was followed by a 14-day treatment with BK+Ca and K+ATP openers.
T5 587-823 Sentence denotes The outcome measures were airway smooth muscle cells reactivity in vivo and in vitro, cilia beating frequency and the level of exhaled NO (ENO), and the level of pro-inflammatory cytokines in the plasma and bronchoalveolar lavage fluid.
T5 587-823 Sentence denotes The outcome measures were airway smooth muscle cells reactivity in vivo and in vitro, cilia beating frequency and the level of exhaled NO (ENO), and the level of pro-inflammatory cytokines in the plasma and bronchoalveolar lavage fluid.
T6 824-960 Sentence denotes The openers of both channels decreased airway smooth muscle cells reactivity, cilia beating frequency, and cytokine levels in the serum.
T6 824-960 Sentence denotes The openers of both channels decreased airway smooth muscle cells reactivity, cilia beating frequency, and cytokine levels in the serum.
T7 961-1029 Sentence denotes Furthermore, NS1619 reduced ENO and inflammatory cells infiltration.
T7 961-1029 Sentence denotes Furthermore, NS1619 reduced ENO and inflammatory cells infiltration.
T8 1030-1144 Sentence denotes The findings confirmed the presence of beneficial effects of BK+Ca and K+ATP openers on airway defence mechanisms.
T8 1030-1144 Sentence denotes The findings confirmed the presence of beneficial effects of BK+Ca and K+ATP openers on airway defence mechanisms.
T9 1145-1296 Sentence denotes Although both openers dampened pro-inflammatory cytokines and mast cells infiltration, an evident anti-inflammatory effect was provided only by NS1619.
T9 1145-1296 Sentence denotes Although both openers dampened pro-inflammatory cytokines and mast cells infiltration, an evident anti-inflammatory effect was provided only by NS1619.
T10 1297-1438 Sentence denotes Therefore, we conclude that particularly BK+Ca channels represent a promising new drug target in treatment of airway's allergic inflammation.
T10 1297-1438 Sentence denotes Therefore, we conclude that particularly BK+Ca channels represent a promising new drug target in treatment of airway's allergic inflammation.