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PubMed:25230104 JSONTXT 26 Projects

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Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes Longitudinal study of circulating protein biomarkers in inflammatory bowel disease.
T1 0-83 Sentence denotes Longitudinal study of circulating protein biomarkers in inflammatory bowel disease.
T2 84-95 Sentence denotes UNLABELLED:
T2 84-95 Sentence denotes UNLABELLED:
T3 96-212 Sentence denotes Inflammatory bowel diseases (IBDs) are chronic and progressive inflammatory disorders of the gastrointestinal tract.
T3 96-212 Sentence denotes Inflammatory bowel diseases (IBDs) are chronic and progressive inflammatory disorders of the gastrointestinal tract.
T4 213-368 Sentence denotes In IBD, protein serological biomarkers could be relevant tools for assessing disease activity, performing early-stage diagnosis and managing the treatment.
T4 213-368 Sentence denotes In IBD, protein serological biomarkers could be relevant tools for assessing disease activity, performing early-stage diagnosis and managing the treatment.
T5 369-587 Sentence denotes Using the interleukin-10 knockout (IL-10(-/-)) mouse, a model that develops a time-dependent IBD-like disorder that predominates in the colon; we performed longitudinal studies of circulating protein biomarkers in IBD.
T5 369-587 Sentence denotes Using the interleukin-10 knockout (IL-10(-/-)) mouse, a model that develops a time-dependent IBD-like disorder that predominates in the colon; we performed longitudinal studies of circulating protein biomarkers in IBD.
T6 588-806 Sentence denotes Circulating protein profiles in serum samples collected from 30-, 93-, to 135-day-old IL-10(-/-) mice were investigated using two-dimensional differential gel electrophoresis and MALDI-TOF/TOF tandem mass spectrometry.
T6 588-806 Sentence denotes Circulating protein profiles in serum samples collected from 30-, 93-, to 135-day-old IL-10(-/-) mice were investigated using two-dimensional differential gel electrophoresis and MALDI-TOF/TOF tandem mass spectrometry.
T7 807-1033 Sentence denotes A total of 15 different proteins were identified and confirmed by ELISA and Western blot to be differentially accumulated in serum samples from mid- to late-stage IL-10(-/-) mice compared to early non-inflamed IL-10(-/-) mice.
T7 807-1033 Sentence denotes A total of 15 different proteins were identified and confirmed by ELISA and Western blot to be differentially accumulated in serum samples from mid- to late-stage IL-10(-/-) mice compared to early non-inflamed IL-10(-/-) mice.
T8 1034-1305 Sentence denotes The use of another model of colitis and an extra-intestinal inflammation model validated this biomarker panel and demonstrated that comprised some global inflammatory markers, some intestinal inflammation-specific markers and some chronic intestinal inflammation markers.
T8 1034-1305 Sentence denotes The use of another model of colitis and an extra-intestinal inflammation model validated this biomarker panel and demonstrated that comprised some global inflammatory markers, some intestinal inflammation-specific markers and some chronic intestinal inflammation markers.
T9 1306-1450 Sentence denotes Statistical analyses using misclassification error rate charts validated the use of these identified proteins as powerful biomarkers of colitis.
T9 1306-1450 Sentence denotes Statistical analyses using misclassification error rate charts validated the use of these identified proteins as powerful biomarkers of colitis.
T10 1451-1618 Sentence denotes Unlike standard biomarker screening studies, our analyses identified a panel of proteins that allowed the definition of protein signatures that reflect colitis status.
T10 1451-1618 Sentence denotes Unlike standard biomarker screening studies, our analyses identified a panel of proteins that allowed the definition of protein signatures that reflect colitis status.
T11 1619-1643 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T11 1619-1643 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T12 1644-1768 Sentence denotes Crohn's disease (CD) and ulcerative colitis (UC) are the most common inflammatory bowel diseases (IBDs) occurring in humans.
T12 1644-1768 Sentence denotes Crohn's disease (CD) and ulcerative colitis (UC) are the most common inflammatory bowel diseases (IBDs) occurring in humans.
T13 1769-1870 Sentence denotes The major current diagnosis tool is colonoscopy, which is invasive and could lead to false diagnosis.
T13 1769-1870 Sentence denotes The major current diagnosis tool is colonoscopy, which is invasive and could lead to false diagnosis.
T14 1871-2006 Sentence denotes The emergence of serological biomarkers enables the use of new diagnosis tools such as protein signatures for IBD diagnosis/management.
T14 1871-2006 Sentence denotes The emergence of serological biomarkers enables the use of new diagnosis tools such as protein signatures for IBD diagnosis/management.
T15 2007-2178 Sentence denotes Using 2D-DIGE coupled to mass spectrometry, our longitudinal study in a mouse model of colitis identified a signature of protein biomarkers for specific stages of disease.
T15 2007-2178 Sentence denotes Using 2D-DIGE coupled to mass spectrometry, our longitudinal study in a mouse model of colitis identified a signature of protein biomarkers for specific stages of disease.