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PubMed:25218136 JSONTXT 26 Projects

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Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.
T1 0-100 Sentence denotes Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.
T2 101-380 Sentence denotes The present study tested the hypothesis that sepsis-induced leucine (Leu) resistance in skeletal muscle is associated with a down-regulation of amino acid transporters important in regulating Leu flux or an impairment in the formation of the Leu-sensitive mTOR-Ragulator complex.
T2 101-380 Sentence denotes The present study tested the hypothesis that sepsis-induced leucine (Leu) resistance in skeletal muscle is associated with a down-regulation of amino acid transporters important in regulating Leu flux or an impairment in the formation of the Leu-sensitive mTOR-Ragulator complex.
T3 381-564 Sentence denotes Sepsis in adult male rats decreased basal protein synthesis in gastrocnemius, associated with a reduction in mTOR activation as indicated by decreased 4E-BP1 and S6K1 phosphorylation.
T3 381-564 Sentence denotes Sepsis in adult male rats decreased basal protein synthesis in gastrocnemius, associated with a reduction in mTOR activation as indicated by decreased 4E-BP1 and S6K1 phosphorylation.
T4 565-677 Sentence denotes The ability of oral Leu to increase protein synthesis and mTOR kinase after 1 h was largely prevented in sepsis.
T4 565-677 Sentence denotes The ability of oral Leu to increase protein synthesis and mTOR kinase after 1 h was largely prevented in sepsis.
T5 678-824 Sentence denotes Sepsis increased CAT1, LAT2 and SNAT2 mRNA content two- to fourfold, but only the protein content for CAT1 (20 % decrease) differed significantly.
T5 678-824 Sentence denotes Sepsis increased CAT1, LAT2 and SNAT2 mRNA content two- to fourfold, but only the protein content for CAT1 (20 % decrease) differed significantly.
T6 825-967 Sentence denotes Conversely, sepsis decreased the proton-assisted amino acid transporter (PAT)-2 mRNA by 60 %, but without a coordinate change in PAT2 protein.
T6 825-967 Sentence denotes Conversely, sepsis decreased the proton-assisted amino acid transporter (PAT)-2 mRNA by 60 %, but without a coordinate change in PAT2 protein.
T7 968-1085 Sentence denotes There was no sepsis or Leu effect on the protein content for RagA-D, LAMTOR-1 and -2, raptor, Rheb or mTOR in muscle.
T7 968-1085 Sentence denotes There was no sepsis or Leu effect on the protein content for RagA-D, LAMTOR-1 and -2, raptor, Rheb or mTOR in muscle.
T8 1086-1325 Sentence denotes The binding of mTOR, PRAS40 and RagC to raptor did not differ for control and septic muscle in the basal condition; however, the Leu-induced decrease in PRAS40·raptor and increase in RagC·raptor seen in control muscle was absent in sepsis.
T8 1086-1325 Sentence denotes The binding of mTOR, PRAS40 and RagC to raptor did not differ for control and septic muscle in the basal condition; however, the Leu-induced decrease in PRAS40·raptor and increase in RagC·raptor seen in control muscle was absent in sepsis.
T9 1326-1541 Sentence denotes The intracellular Leu concentration was increased in septic muscle, compared to basal control conditions, and oral Leu further increased the intracellular Leu concentration similarly in both control and septic rats.
T9 1326-1541 Sentence denotes The intracellular Leu concentration was increased in septic muscle, compared to basal control conditions, and oral Leu further increased the intracellular Leu concentration similarly in both control and septic rats.
T10 1542-1886 Sentence denotes Hence, while alterations in select amino acid transporters are not associated with development of sepsis-induced Leu resistance, the Leu-stimulated binding of raptor with RagC and the recruitment of mTOR/raptor to the endosome-lysosomal compartment may partially explain the inability of Leu to fully activate mTOR and muscle protein synthesis.
T10 1542-1886 Sentence denotes Hence, while alterations in select amino acid transporters are not associated with development of sepsis-induced Leu resistance, the Leu-stimulated binding of raptor with RagC and the recruitment of mTOR/raptor to the endosome-lysosomal compartment may partially explain the inability of Leu to fully activate mTOR and muscle protein synthesis.