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PubMed:25125695 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-81 Sentence denotes FHL2 regulates the resolution of tissue damage in chronic inflammatory arthritis.
T1 0-81 Sentence denotes FHL2 regulates the resolution of tissue damage in chronic inflammatory arthritis.
T2 82-92 Sentence denotes OBJECTIVE:
T2 82-92 Sentence denotes OBJECTIVE:
T3 93-365 Sentence denotes We analysed the role of the adaptor molecule four-and-a-half Lin11, Isl-1 & Mec-3 (LIM) domain protein 2 (FHL2) in the activation of fibroblast-like synoviocytes in human rheumatoid arthritis (RA) and tumour necrosis factor α (TNFα)-dependent animal models of the disease.
T3 93-365 Sentence denotes We analysed the role of the adaptor molecule four-and-a-half Lin11, Isl-1 & Mec-3 (LIM) domain protein 2 (FHL2) in the activation of fibroblast-like synoviocytes in human rheumatoid arthritis (RA) and tumour necrosis factor α (TNFα)-dependent animal models of the disease.
T4 366-374 Sentence denotes METHODS:
T4 366-374 Sentence denotes METHODS:
T5 375-566 Sentence denotes Synovial tissues of patients with RA and osteoarthritis (OA) as well as hind paw sections from arthritic human TNFα transgenic (hTNFtg) mice and synovial fibroblasts from these were analysed.
T5 375-566 Sentence denotes Synovial tissues of patients with RA and osteoarthritis (OA) as well as hind paw sections from arthritic human TNFα transgenic (hTNFtg) mice and synovial fibroblasts from these were analysed.
T6 567-685 Sentence denotes The effects of cytokines on the expression of FHL2 and disease-relevant matrixmetalloproteases (MMPs) were determined.
T6 567-685 Sentence denotes The effects of cytokines on the expression of FHL2 and disease-relevant matrixmetalloproteases (MMPs) were determined.
T7 686-867 Sentence denotes Analyses of human tissue specimens from patients treated with anti-TNFα as well as anti-TNFα treatment of hTNFtg mice were performed to substantiate the TNFα effects on FHL2 levels.
T7 686-867 Sentence denotes Analyses of human tissue specimens from patients treated with anti-TNFα as well as anti-TNFα treatment of hTNFtg mice were performed to substantiate the TNFα effects on FHL2 levels.
T8 868-1023 Sentence denotes FHL2(-/-) mice and hTNFtg mice (with constitutive or inducible transgene expression) were crossbred to generate TNFα overexpressing FHL2-deficient animals.
T8 868-1023 Sentence denotes FHL2(-/-) mice and hTNFtg mice (with constitutive or inducible transgene expression) were crossbred to generate TNFα overexpressing FHL2-deficient animals.
T9 1024-1143 Sentence denotes Signalling pathways were analysed in cells from these mice and in human cells after knock down of FHL2 by western blot.
T9 1024-1143 Sentence denotes Signalling pathways were analysed in cells from these mice and in human cells after knock down of FHL2 by western blot.
T10 1144-1231 Sentence denotes RESULTS: FHL2 levels were higher in RA than in OA and in hTNFtg than in wild-type mice.
T10 1144-1231 Sentence denotes RESULTS: FHL2 levels were higher in RA than in OA and in hTNFtg than in wild-type mice.
T11 1232-1332 Sentence denotes Surprisingly, while transforming growth factor (TGF)β-induced FHL2 expression, TNFα suppressed FHL2.
T11 1232-1332 Sentence denotes Surprisingly, while transforming growth factor (TGF)β-induced FHL2 expression, TNFα suppressed FHL2.
T12 1333-1424 Sentence denotes In vivo, anti-TNFα treatment led to higher FHL2 levels both in RA patients and hTNFtg mice.
T12 1333-1424 Sentence denotes In vivo, anti-TNFα treatment led to higher FHL2 levels both in RA patients and hTNFtg mice.
T13 1425-1527 Sentence denotes The loss of FHL2 increased joint destruction in hTNFtg mice, which was accompanied by elevated MMP-13.
T13 1425-1527 Sentence denotes The loss of FHL2 increased joint destruction in hTNFtg mice, which was accompanied by elevated MMP-13.
T14 1528-1683 Sentence denotes In vitro, TNFα-mediated MMP-13 was significantly higher in FHL2(-/-) cells and after knock down of FHL2, which was caused by prolonged p38 MAPK activation.
T14 1528-1683 Sentence denotes In vitro, TNFα-mediated MMP-13 was significantly higher in FHL2(-/-) cells and after knock down of FHL2, which was caused by prolonged p38 MAPK activation.
T15 1684-1696 Sentence denotes CONCLUSIONS:
T15 1684-1696 Sentence denotes CONCLUSIONS:
T16 1697-1876 Sentence denotes These data suggest that FHL2 serves as a protective factor and that, rather than promoting the pathology, the upregulation of FHL2 in RA occurs in frame of a regenerative attempt.
T16 1697-1876 Sentence denotes These data suggest that FHL2 serves as a protective factor and that, rather than promoting the pathology, the upregulation of FHL2 in RA occurs in frame of a regenerative attempt.