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PubMed:24957054 JSONTXT 69 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-66 Sentence denotes Galectin-8 elicits pro-inflammatory activities in the endothelium.
T1 0-66 Sentence denotes Galectin-8 elicits pro-inflammatory activities in the endothelium.
T2 67-183 Sentence denotes Galectins (Gals), a family of mammalian lectins, play diverse roles under physiological and pathological conditions.
T2 67-183 Sentence denotes Galectins (Gals), a family of mammalian lectins, play diverse roles under physiological and pathological conditions.
T3 184-289 Sentence denotes Here, we analyzed the tandem-repeat Gal-8 synthesis, secretion and effects on the endothelium physiology.
T3 184-289 Sentence denotes Here, we analyzed the tandem-repeat Gal-8 synthesis, secretion and effects on the endothelium physiology.
T4 290-404 Sentence denotes Gal-8M and Gal-8L isoforms were secreted under basal conditions by human microvascular endothelial cells (HMEC-1).
T4 290-404 Sentence denotes Gal-8M and Gal-8L isoforms were secreted under basal conditions by human microvascular endothelial cells (HMEC-1).
T5 405-601 Sentence denotes However, expression and secretion of the Gal-8M isoform, but not Gal-8L, were increased in response to bacterial lipopolysaccharide (LPS) stimulus and returned to control values after LPS removal.
T5 405-601 Sentence denotes However, expression and secretion of the Gal-8M isoform, but not Gal-8L, were increased in response to bacterial lipopolysaccharide (LPS) stimulus and returned to control values after LPS removal.
T6 602-682 Sentence denotes Similarly, cell surface Gal-8 exposure was increased after stimulation with LPS.
T6 602-682 Sentence denotes Similarly, cell surface Gal-8 exposure was increased after stimulation with LPS.
T7 683-806 Sentence denotes To evaluate Gal-8 effects on the endothelium physiology, HMEC-1 cells were incubated in the presence of recombinant Gal-8M.
T7 683-806 Sentence denotes To evaluate Gal-8 effects on the endothelium physiology, HMEC-1 cells were incubated in the presence of recombinant Gal-8M.
T8 807-936 Sentence denotes Pretreated HMEC-1 cells became proadhesive to human normal platelets, indicating that Gal-8 actually activates endothelial cells.
T8 807-936 Sentence denotes Pretreated HMEC-1 cells became proadhesive to human normal platelets, indicating that Gal-8 actually activates endothelial cells.
T9 937-1062 Sentence denotes This effect was specific for lectin activity as it was prevented by the simultaneous addition of lactose, but not by sucrose.
T9 937-1062 Sentence denotes This effect was specific for lectin activity as it was prevented by the simultaneous addition of lactose, but not by sucrose.
T10 1063-1285 Sentence denotes Endothelial cells also increased their exposition of von Willebrand factor after Gal-8 treatment, which constitutes another feature of cell activation that could be, in turn, responsible for the observed platelet adhesion.
T10 1063-1285 Sentence denotes Endothelial cells also increased their exposition of von Willebrand factor after Gal-8 treatment, which constitutes another feature of cell activation that could be, in turn, responsible for the observed platelet adhesion.
T11 1286-1499 Sentence denotes Several pro-inflammatory molecules were abundantly produced by Gal-8 stimulated endothelial cells: CXCL1 (GRO-α), GM-CSF, IL-6 and CCL5 (RANTES), and in a lower degree CCL2 (MCP-1), CXCL3 (GRO-γ) and CXCL8 (IL-8).
T11 1286-1499 Sentence denotes Several pro-inflammatory molecules were abundantly produced by Gal-8 stimulated endothelial cells: CXCL1 (GRO-α), GM-CSF, IL-6 and CCL5 (RANTES), and in a lower degree CCL2 (MCP-1), CXCL3 (GRO-γ) and CXCL8 (IL-8).
T12 1500-1568 Sentence denotes In agreement, Gal-8M induced nuclear factor kappa B phosphorylation.
T12 1500-1568 Sentence denotes In agreement, Gal-8M induced nuclear factor kappa B phosphorylation.
T13 1569-1818 Sentence denotes Altogether, these results not only confirm the pro-inflammatory role we have already proposed for Gal-8 in other cellular systems but also suggest that this lectin is orchestrating the interaction between leukocytes, platelets and endothelial cells.
T13 1569-1818 Sentence denotes Altogether, these results not only confirm the pro-inflammatory role we have already proposed for Gal-8 in other cellular systems but also suggest that this lectin is orchestrating the interaction between leukocytes, platelets and endothelial cells.