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PubMed:24842192 JSONTXT 26 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-151 Sentence denotes Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction.
T1 0-151 Sentence denotes Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction.
T2 152-330 Sentence denotes Acute treatment with metformin has a protective effect in myocardial infarction by suppression of inflammatory responses due to activation of AMP-activated protein kinase (AMPK).
T2 152-330 Sentence denotes Acute treatment with metformin has a protective effect in myocardial infarction by suppression of inflammatory responses due to activation of AMP-activated protein kinase (AMPK).
T3 331-545 Sentence denotes In the present study, the effect of chronic pre-treatment with metformin on cardiac dysfunction and toll-like receptor 4 (TLR4) activities following myocardial infarction and their relation with AMPK were assessed.
T3 331-545 Sentence denotes In the present study, the effect of chronic pre-treatment with metformin on cardiac dysfunction and toll-like receptor 4 (TLR4) activities following myocardial infarction and their relation with AMPK were assessed.
T4 546-759 Sentence denotes Male Wistar rats were randomly assigned to one of 5 groups (n=6): normal control and groups were injected isoproterenol after chronic pre-treatment with 0, 25, 50, or 100mg/kg of metformin twice daily for 14 days.
T4 546-759 Sentence denotes Male Wistar rats were randomly assigned to one of 5 groups (n=6): normal control and groups were injected isoproterenol after chronic pre-treatment with 0, 25, 50, or 100mg/kg of metformin twice daily for 14 days.
T5 760-877 Sentence denotes Isoproterenol (100mg/kg) was injected subcutaneously on the 13th and 14th days to induce acute myocardial infarction.
T5 760-877 Sentence denotes Isoproterenol (100mg/kg) was injected subcutaneously on the 13th and 14th days to induce acute myocardial infarction.
T6 878-1009 Sentence denotes Isoproterenol alone decreased left ventricular systolic pressure and myocardial contractility indexed as LVdp/dtmax and LVdp/dtmin.
T6 878-1009 Sentence denotes Isoproterenol alone decreased left ventricular systolic pressure and myocardial contractility indexed as LVdp/dtmax and LVdp/dtmin.
T7 1010-1122 Sentence denotes The left ventricular dysfunction was significantly lower in the groups treated with 25 and 50mg/kg of metformin.
T7 1010-1122 Sentence denotes The left ventricular dysfunction was significantly lower in the groups treated with 25 and 50mg/kg of metformin.
T8 1123-1337 Sentence denotes Metfromin markedly lowered isoproterenol-induced elevation in the levels of TLR4 mRNA, myeloid differentiation protein 88 (MyD88), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) in the heart tissues.
T8 1123-1337 Sentence denotes Metfromin markedly lowered isoproterenol-induced elevation in the levels of TLR4 mRNA, myeloid differentiation protein 88 (MyD88), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) in the heart tissues.
T9 1338-1407 Sentence denotes Similar changes were also seen in the serum levels of TNF-α and IL-6.
T9 1338-1407 Sentence denotes Similar changes were also seen in the serum levels of TNF-α and IL-6.
T10 1408-1485 Sentence denotes However, the lower doses of 25 and 50mg/kg were more effective than 100mg/kg.
T10 1408-1485 Sentence denotes However, the lower doses of 25 and 50mg/kg were more effective than 100mg/kg.
T11 1486-1627 Sentence denotes Phosphorylated AMPKα (p-AMPK) in the myocardium was significantly elevated by 25mg/kg of metformin, slightly by 50mg/kg, but not by 100mg/kg.
T11 1486-1627 Sentence denotes Phosphorylated AMPKα (p-AMPK) in the myocardium was significantly elevated by 25mg/kg of metformin, slightly by 50mg/kg, but not by 100mg/kg.
T12 1628-1806 Sentence denotes Chronic pre-treatment with metformin reduces post-myocardial infarction cardiac dysfunction and suppresses inflammatory responses, possibly through inhibition of TLR4 activities.
T12 1628-1806 Sentence denotes Chronic pre-treatment with metformin reduces post-myocardial infarction cardiac dysfunction and suppresses inflammatory responses, possibly through inhibition of TLR4 activities.
T13 1807-1884 Sentence denotes This mechanism can be considered as a target to protect infarcted myocardium.
T13 1807-1884 Sentence denotes This mechanism can be considered as a target to protect infarcted myocardium.