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PubMed:24628819 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-150 Sentence denotes IL10 single nucleotide polymorphisms are related to upregulation of constitutive IL-10 production and susceptibility to Helicobacter pylori infection.
T1 0-150 Sentence denotes IL10 single nucleotide polymorphisms are related to upregulation of constitutive IL-10 production and susceptibility to Helicobacter pylori infection.
T2 151-162 Sentence denotes BACKGROUND:
T2 151-162 Sentence denotes BACKGROUND:
T3 163-325 Sentence denotes Helicobacter pylori infection is a strong risk factor for gastric cancer, likely due to the extensive inflammation in the stomach mucosa caused by these bacteria.
T3 163-325 Sentence denotes Helicobacter pylori infection is a strong risk factor for gastric cancer, likely due to the extensive inflammation in the stomach mucosa caused by these bacteria.
T4 326-445 Sentence denotes Many studies have reported an association between IL10 polymorphisms, the risk of gastric cancer, and IL-10 production.
T4 326-445 Sentence denotes Many studies have reported an association between IL10 polymorphisms, the risk of gastric cancer, and IL-10 production.
T5 446-625 Sentence denotes The aim of the study was to evaluate the association between IL10 genetic variants, Helicobacter pylori infection, and IL-10 production by peripheral blood leukocytes in children.
T5 446-625 Sentence denotes The aim of the study was to evaluate the association between IL10 genetic variants, Helicobacter pylori infection, and IL-10 production by peripheral blood leukocytes in children.
T6 626-648 Sentence denotes MATERIALS AND METHODS:
T6 626-648 Sentence denotes MATERIALS AND METHODS:
T7 649-872 Sentence denotes We genotyped a total of 12 single nucleotide polymorphisms in IL10 in 1259 children aged 4-11 years living in a poor urban area in Salvador, Brazil, using TaqMan probe based, 5' nuclease assay minor groove binder chemistry.
T7 649-872 Sentence denotes We genotyped a total of 12 single nucleotide polymorphisms in IL10 in 1259 children aged 4-11 years living in a poor urban area in Salvador, Brazil, using TaqMan probe based, 5' nuclease assay minor groove binder chemistry.
T8 873-1146 Sentence denotes Association tests were performed by logistic regression for Helicobacter pylori infection and linear regression for IL-10 spontaneous production (whole-blood cultures) including sex, age, and principal components for informative ancestry markers as covariates, using PLINK.
T8 873-1146 Sentence denotes Association tests were performed by logistic regression for Helicobacter pylori infection and linear regression for IL-10 spontaneous production (whole-blood cultures) including sex, age, and principal components for informative ancestry markers as covariates, using PLINK.
T9 1147-1155 Sentence denotes RESULTS:
T9 1147-1155 Sentence denotes RESULTS:
T10 1156-1453 Sentence denotes Our results shown that IL10 single nucleotide polymorphisms rs1800896 (OR = 1.63; 95% CI = 1.11-2.39), rs3024491 (OR = 1.71; 95% CI = 1.14-2.57), rs1878672 (OR = 1.79; 95% CI = 1.19-2.68), and rs3024496 (OR = 1.48; 95% CI = 1.05-2.08) were positively associated with Helicobacter pylori infection.
T10 1156-1453 Sentence denotes Our results shown that IL10 single nucleotide polymorphisms rs1800896 (OR = 1.63; 95% CI = 1.11-2.39), rs3024491 (OR = 1.71; 95% CI = 1.14-2.57), rs1878672 (OR = 1.79; 95% CI = 1.19-2.68), and rs3024496 (OR = 1.48; 95% CI = 1.05-2.08) were positively associated with Helicobacter pylori infection.
T11 1454-1690 Sentence denotes Eight single nucleotide polymorphisms were associated with spontaneous production of IL-10 in culture, of which three (rs1800896 and rs1878672, p = .04; rs3024491, p = .01) were strongly associated with infection by Helicobacter pylori.
T11 1454-1690 Sentence denotes Eight single nucleotide polymorphisms were associated with spontaneous production of IL-10 in culture, of which three (rs1800896 and rs1878672, p = .04; rs3024491, p = .01) were strongly associated with infection by Helicobacter pylori.
T12 1691-1703 Sentence denotes CONCLUSIONS:
T12 1691-1703 Sentence denotes CONCLUSIONS:
T13 1704-1906 Sentence denotes Our results indicate that IL10 variants rs1800896, rs3024491, rs1878672, and rs3024496 are more consistently associated with the presence of anti-H. pylori IgG by inducing increased production of IL-10.
T13 1704-1906 Sentence denotes Our results indicate that IL10 variants rs1800896, rs3024491, rs1878672, and rs3024496 are more consistently associated with the presence of anti-H. pylori IgG by inducing increased production of IL-10.
T14 1907-2057 Sentence denotes Further studies are underway to elucidate the role of additional genetic variants and to investigate their impact on the occurrence of gastric cancer.
T14 1907-2057 Sentence denotes Further studies are underway to elucidate the role of additional genetic variants and to investigate their impact on the occurrence of gastric cancer.