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PubMed:24283717 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.
T1 0-127 Sentence denotes Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.
T2 128-151 Sentence denotes BACKGROUND AND PURPOSE:
T2 128-151 Sentence denotes BACKGROUND AND PURPOSE:
T3 152-255 Sentence denotes Retinal neurodegeneration is an early and critical event in several diseases associated with blindness.
T3 152-255 Sentence denotes Retinal neurodegeneration is an early and critical event in several diseases associated with blindness.
T4 256-313 Sentence denotes Clinically, therapies that target neurodegeneration fail.
T4 256-313 Sentence denotes Clinically, therapies that target neurodegeneration fail.
T5 314-467 Sentence denotes We aimed to elucidate the multiple roles by which thioredoxin-interacting protein (TXNIP) contributes to initial and sustained retinal neurodegeneration.
T5 314-467 Sentence denotes We aimed to elucidate the multiple roles by which thioredoxin-interacting protein (TXNIP) contributes to initial and sustained retinal neurodegeneration.
T6 468-490 Sentence denotes EXPERIMENTAL APPROACH:
T6 468-490 Sentence denotes EXPERIMENTAL APPROACH:
T7 491-601 Sentence denotes Neurotoxicity was induced by intravitreal injection of NMDA into wild-type (WT) and TXNIP-knockout (TKO) mice.
T7 491-601 Sentence denotes Neurotoxicity was induced by intravitreal injection of NMDA into wild-type (WT) and TXNIP-knockout (TKO) mice.
T8 602-716 Sentence denotes The expression of apoptotic and inflammatory markers was assessed by immunohistochemistry, elisa and Western blot.
T8 602-716 Sentence denotes The expression of apoptotic and inflammatory markers was assessed by immunohistochemistry, elisa and Western blot.
T9 717-849 Sentence denotes Microvascular degeneration was assessed by periodic acid-Schiff and haematoxylin staining and retinal function by electroretinogram.
T9 717-849 Sentence denotes Microvascular degeneration was assessed by periodic acid-Schiff and haematoxylin staining and retinal function by electroretinogram.
T10 850-1078 Sentence denotes KEY RESULTS: NMDA induced early (1 day) and significant retinal PARP activation, a threefold increase in TUNEL-positive nuclei and 40% neuronal loss in ganglion cell layer (GCL); and vascular permeability in WT but not TKO mice.
T10 850-1078 Sentence denotes KEY RESULTS: NMDA induced early (1 day) and significant retinal PARP activation, a threefold increase in TUNEL-positive nuclei and 40% neuronal loss in ganglion cell layer (GCL); and vascular permeability in WT but not TKO mice.
T11 1079-1199 Sentence denotes NMDA induced glial activation, expression of TNF-α and IL-1β that co-localized with Müller cells in WT but not TKO mice.
T11 1079-1199 Sentence denotes NMDA induced glial activation, expression of TNF-α and IL-1β that co-localized with Müller cells in WT but not TKO mice.
T12 1200-1379 Sentence denotes In parallel, NMDA triggered the expression of NOD-like receptor protein (NLRP3), activation of caspase-1, and release of IL-1β and TNF-α in primary WT but not TKO Müller cultures.
T12 1200-1379 Sentence denotes In parallel, NMDA triggered the expression of NOD-like receptor protein (NLRP3), activation of caspase-1, and release of IL-1β and TNF-α in primary WT but not TKO Müller cultures.
T13 1380-1563 Sentence denotes After 14 days, NMDA induced 1.9-fold microvascular degeneration, 60% neuronal loss in GCL and increased TUNEL-labelled cells in the GCL and inner nuclear layer in WT but not TKO mice.
T13 1380-1563 Sentence denotes After 14 days, NMDA induced 1.9-fold microvascular degeneration, 60% neuronal loss in GCL and increased TUNEL-labelled cells in the GCL and inner nuclear layer in WT but not TKO mice.
T14 1564-1670 Sentence denotes Electroretinogram analysis showed more significant reductions in b-wave amplitudes in WT than in TKO mice.
T14 1564-1670 Sentence denotes Electroretinogram analysis showed more significant reductions in b-wave amplitudes in WT than in TKO mice.
T15 1671-1699 Sentence denotes CONCLUSION AND IMPLICATIONS:
T15 1671-1699 Sentence denotes CONCLUSION AND IMPLICATIONS:
T16 1700-1889 Sentence denotes Targeting TXNIP expression prevented early retinal ganglion cell death, glial activation, retinal inflammation and secondary neuro/microvascular degeneration and preserved retinal function.
T16 1700-1889 Sentence denotes Targeting TXNIP expression prevented early retinal ganglion cell death, glial activation, retinal inflammation and secondary neuro/microvascular degeneration and preserved retinal function.
T17 1890-1973 Sentence denotes TXNIP is a promising new therapeutic target for retinal neurodegenerative diseases.
T17 1890-1973 Sentence denotes TXNIP is a promising new therapeutic target for retinal neurodegenerative diseases.