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PubMed:23838176 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1 0-158 Sentence denotes Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.
T1 0-158 Sentence denotes Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.
T2 159-322 Sentence denotes Alzheimer's disease (AD) is characterized by amyloid-β deposition in amyloid plaques, neurofibrillary tangles, inflammation, neuronal loss, and cognitive deficits.
T2 159-322 Sentence denotes Alzheimer's disease (AD) is characterized by amyloid-β deposition in amyloid plaques, neurofibrillary tangles, inflammation, neuronal loss, and cognitive deficits.
T3 323-418 Sentence denotes Cannabinoids display neuromodulatory and neuroprotective effects and affect memory acquisition.
T3 323-418 Sentence denotes Cannabinoids display neuromodulatory and neuroprotective effects and affect memory acquisition.
T4 419-647 Sentence denotes Here, we studied the impact of cannabinoid receptor type 1 (CB1) deficiency on the development of AD pathology by breeding amyloid precursor protein (APP) Swedish mutant mice (APP23), an AD animal model, with CB1-deficient mice.
T4 419-647 Sentence denotes Here, we studied the impact of cannabinoid receptor type 1 (CB1) deficiency on the development of AD pathology by breeding amyloid precursor protein (APP) Swedish mutant mice (APP23), an AD animal model, with CB1-deficient mice.
T5 648-796 Sentence denotes In addition to the lower body weight of APP23/CB1(-/-) mice, most of these mice died at an age before typical AD-associated changes become apparent.
T5 648-796 Sentence denotes In addition to the lower body weight of APP23/CB1(-/-) mice, most of these mice died at an age before typical AD-associated changes become apparent.
T6 797-983 Sentence denotes The surviving mice showed a reduced amount of APP and its fragments suggesting a regulatory influence of CB1 on APP processing, which was confirmed by modulating CB1 expression in vitro.
T6 797-983 Sentence denotes The surviving mice showed a reduced amount of APP and its fragments suggesting a regulatory influence of CB1 on APP processing, which was confirmed by modulating CB1 expression in vitro.
T7 984-1090 Sentence denotes Reduced APP levels were accompanied by a reduced plaque load and less inflammation in APP23/CB1(-/-) mice.
T7 984-1090 Sentence denotes Reduced APP levels were accompanied by a reduced plaque load and less inflammation in APP23/CB1(-/-) mice.
T8 1091-1213 Sentence denotes Nevertheless, compared to APP23 mice with an intact CB1, APP23/CB1(-/-) mice showed impaired learning and memory deficits.
T8 1091-1213 Sentence denotes Nevertheless, compared to APP23 mice with an intact CB1, APP23/CB1(-/-) mice showed impaired learning and memory deficits.
T9 1214-1343 Sentence denotes These data argue against a direct correlation of amyloid plaque load with cognitive abilities in this AD mouse model lacking CB1.
T9 1214-1343 Sentence denotes These data argue against a direct correlation of amyloid plaque load with cognitive abilities in this AD mouse model lacking CB1.
T10 1344-1502 Sentence denotes Furthermore, the findings indicate that CB1 deficiency can worsen AD-related cognitive deficits and support a potential role of CB1 as a pharmacologic target.
T10 1344-1502 Sentence denotes Furthermore, the findings indicate that CB1 deficiency can worsen AD-related cognitive deficits and support a potential role of CB1 as a pharmacologic target.