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PubMed:23736221 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project.
T1 0-132 Sentence denotes The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project.
T2 133-282 Sentence denotes Epistasis between interleukin-10 (IL10) and aromatase gene polymorphisms has previously been reported to modify the risk of Alzheimer's disease (AD).
T2 133-282 Sentence denotes Epistasis between interleukin-10 (IL10) and aromatase gene polymorphisms has previously been reported to modify the risk of Alzheimer's disease (AD).
T3 283-472 Sentence denotes However, although the main effects of aromatase variants suggest a sex-specific effect in AD, there has been insufficient power to detect sex-specific epistasis between these genes to date.
T3 283-472 Sentence denotes However, although the main effects of aromatase variants suggest a sex-specific effect in AD, there has been insufficient power to detect sex-specific epistasis between these genes to date.
T4 473-560 Sentence denotes Here we used the cohort of 1757 AD patients and 6294 controls in the Epistasis Project.
T4 473-560 Sentence denotes Here we used the cohort of 1757 AD patients and 6294 controls in the Epistasis Project.
T5 561-751 Sentence denotes We replicated the previously reported main effects of aromatase polymorphisms in AD risk in women, for example, adjusted odds ratio of disease for rs1065778 GG=1.22 (95% confidence interval:
T5 561-751 Sentence denotes We replicated the previously reported main effects of aromatase polymorphisms in AD risk in women, for example, adjusted odds ratio of disease for rs1065778 GG=1.22 (95% confidence interval:
T6 752-771 Sentence denotes 1.01-1.48, P=0.03).
T6 752-771 Sentence denotes 1.01-1.48, P=0.03).
T7 772-949 Sentence denotes We also confirmed a reported epistatic interaction between IL10 rs1800896 and aromatase (CYP19A1) rs1062033, again only in women: adjusted synergy factor=1.94 (1.16-3.25, 0.01).
T7 772-949 Sentence denotes We also confirmed a reported epistatic interaction between IL10 rs1800896 and aromatase (CYP19A1) rs1062033, again only in women: adjusted synergy factor=1.94 (1.16-3.25, 0.01).
T8 950-1098 Sentence denotes Aromatase, a rate-limiting enzyme in the synthesis of estrogens, is expressed in AD-relevant brain regions ,and is downregulated during the disease.
T8 950-1098 Sentence denotes Aromatase, a rate-limiting enzyme in the synthesis of estrogens, is expressed in AD-relevant brain regions ,and is downregulated during the disease.
T9 1099-1138 Sentence denotes IL-10 is an anti-inflammatory cytokine.
T9 1099-1138 Sentence denotes IL-10 is an anti-inflammatory cytokine.
T10 1139-1295 Sentence denotes Given that estrogens have neuroprotective and anti-inflammatory activities and regulate microglial cytokine production, epistasis is biologically plausible.
T10 1139-1295 Sentence denotes Given that estrogens have neuroprotective and anti-inflammatory activities and regulate microglial cytokine production, epistasis is biologically plausible.
T11 1296-1478 Sentence denotes Diminishing serum estrogen in postmenopausal women, coupled with suboptimal brain estrogen synthesis, may contribute to the inflammatory state, that is a pathological hallmark of AD.
T11 1296-1478 Sentence denotes Diminishing serum estrogen in postmenopausal women, coupled with suboptimal brain estrogen synthesis, may contribute to the inflammatory state, that is a pathological hallmark of AD.