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PubMed:23680148 JSONTXT 35 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-117 Sentence denotes Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
T1 0-117 Sentence denotes Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
T2 118-181 Sentence denotes The tumor suppressor p53 is frequently mutated in human cancer.
T2 118-181 Sentence denotes The tumor suppressor p53 is frequently mutated in human cancer.
T3 182-288 Sentence denotes Common mutant p53 (mutp53) isoforms can actively promote cancer through gain-of-function (GOF) mechanisms.
T3 182-288 Sentence denotes Common mutant p53 (mutp53) isoforms can actively promote cancer through gain-of-function (GOF) mechanisms.
T4 289-402 Sentence denotes We report that mutp53 prolongs TNF-α-induced NF-κB activation in cultured cells and intestinal organoid cultures.
T4 289-402 Sentence denotes We report that mutp53 prolongs TNF-α-induced NF-κB activation in cultured cells and intestinal organoid cultures.
T5 403-621 Sentence denotes Remarkably, when exposed to dextran sulfate sodium, mice harboring a germline p53 mutation develop severe chronic inflammation and persistent tissue damage, and are highly prone to inflammation-associated colon cancer.
T5 403-621 Sentence denotes Remarkably, when exposed to dextran sulfate sodium, mice harboring a germline p53 mutation develop severe chronic inflammation and persistent tissue damage, and are highly prone to inflammation-associated colon cancer.
T6 622-894 Sentence denotes This mutp53 GOF is manifested by rapid onset of flat dysplastic lesions that progress to invasive carcinoma with mutp53 accumulation and augmented NF-κB activation, faithfully recapitulating features frequently observed in human colitis-associated colorectal cancer (CAC).
T6 622-894 Sentence denotes This mutp53 GOF is manifested by rapid onset of flat dysplastic lesions that progress to invasive carcinoma with mutp53 accumulation and augmented NF-κB activation, faithfully recapitulating features frequently observed in human colitis-associated colorectal cancer (CAC).
T7 895-975 Sentence denotes These findings might explain the early appearance of p53 mutations in human CAC.
T7 895-975 Sentence denotes These findings might explain the early appearance of p53 mutations in human CAC.