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PubMed:23667615 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial.
T1 0-130 Sentence denotes Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial.
T2 131-141 Sentence denotes RATIONALE:
T2 131-141 Sentence denotes RATIONALE:
T3 142-294 Sentence denotes Smoking and inflammation contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD), which involves changes in extracellular matrix.
T3 142-294 Sentence denotes Smoking and inflammation contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD), which involves changes in extracellular matrix.
T4 295-370 Sentence denotes This is thought to contribute to airway remodeling and airflow obstruction.
T4 295-370 Sentence denotes This is thought to contribute to airway remodeling and airflow obstruction.
T5 371-566 Sentence denotes We have previously observed that long-term treatment with inhaled corticosteroids can not only reduce bronchial inflammation, but can also attenuate lung function decline in moderate-severe COPD.
T5 371-566 Sentence denotes We have previously observed that long-term treatment with inhaled corticosteroids can not only reduce bronchial inflammation, but can also attenuate lung function decline in moderate-severe COPD.
T6 567-691 Sentence denotes We hypothesized that inhaled corticosteroids and current smoking modulate bronchial extracellular matrix components in COPD.
T6 567-691 Sentence denotes We hypothesized that inhaled corticosteroids and current smoking modulate bronchial extracellular matrix components in COPD.
T7 692-702 Sentence denotes OBJECTIVE:
T7 692-702 Sentence denotes OBJECTIVE:
T8 703-958 Sentence denotes To compare major extracellular matrix components (elastic fibers; proteoglycans [versican, decorin]; collagens type I and III) in bronchial biopsies 1) after 30-months inhaled steroids treatment or placebo; and 2) between current and ex-smokers with COPD.
T8 703-958 Sentence denotes To compare major extracellular matrix components (elastic fibers; proteoglycans [versican, decorin]; collagens type I and III) in bronchial biopsies 1) after 30-months inhaled steroids treatment or placebo; and 2) between current and ex-smokers with COPD.
T9 959-967 Sentence denotes METHODS:
T9 959-967 Sentence denotes METHODS:
T10 968-1215 Sentence denotes We included 64 moderate-severe, steroid-naive COPD patients (24/40 (ex)-smokers, 62±7 years, 46 (31-54) packyears, post-bronchodilator forced expiratory volume in one second (FEV1) 62±9% predicted) at baseline in this randomized, controlled trial.
T10 968-1215 Sentence denotes We included 64 moderate-severe, steroid-naive COPD patients (24/40 (ex)-smokers, 62±7 years, 46 (31-54) packyears, post-bronchodilator forced expiratory volume in one second (FEV1) 62±9% predicted) at baseline in this randomized, controlled trial.
T11 1216-1306 Sentence denotes 19 and 13 patients received 30-months treatment with fluticasone or placebo, respectively.
T11 1216-1306 Sentence denotes 19 and 13 patients received 30-months treatment with fluticasone or placebo, respectively.
T12 1307-1451 Sentence denotes Bronchial biopsies collected at baseline and after 30 months were studied using (immuno)histochemistry to evaluate extracellular matrix content.
T12 1307-1451 Sentence denotes Bronchial biopsies collected at baseline and after 30 months were studied using (immuno)histochemistry to evaluate extracellular matrix content.
T13 1452-1533 Sentence denotes Percentage and density of stained area were calculated by digital image analysis.
T13 1452-1533 Sentence denotes Percentage and density of stained area were calculated by digital image analysis.
T14 1534-1542 Sentence denotes RESULTS:
T14 1534-1542 Sentence denotes RESULTS:
T15 1543-1728 Sentence denotes 30-Months inhaled steroids increased the percentage stained area of versican (9.6% [CI 0.9 to 18.3%]; p = 0.03) and collagen III (20.6% [CI 3.8 to 37.4%]; p = 0.02) compared to placebo.
T15 1543-1728 Sentence denotes 30-Months inhaled steroids increased the percentage stained area of versican (9.6% [CI 0.9 to 18.3%]; p = 0.03) and collagen III (20.6% [CI 3.8 to 37.4%]; p = 0.02) compared to placebo.
T16 1729-1873 Sentence denotes Increased collagen I staining density correlated with increased post-bronchodilator FEV1 after inhaled steroids treatment (Rs = 0.45, p = 0.04).
T16 1729-1873 Sentence denotes Increased collagen I staining density correlated with increased post-bronchodilator FEV1 after inhaled steroids treatment (Rs = 0.45, p = 0.04).
T17 1874-2008 Sentence denotes There were no differences between smokers and ex-smokers with COPD in percentages and densities for all extracellular matrix proteins.
T17 1874-2008 Sentence denotes There were no differences between smokers and ex-smokers with COPD in percentages and densities for all extracellular matrix proteins.
T18 2009-2021 Sentence denotes CONCLUSIONS:
T18 2009-2021 Sentence denotes CONCLUSIONS:
T19 2022-2169 Sentence denotes These data show that long-term inhaled corticosteroids treatment partially changes the composition of extracellular matrix in moderate-severe COPD.
T19 2022-2169 Sentence denotes These data show that long-term inhaled corticosteroids treatment partially changes the composition of extracellular matrix in moderate-severe COPD.
T20 2170-2344 Sentence denotes This is associated with increased lung function, suggesting that long-term inhaled steroids modulate airway remodeling thereby potentially preventing airway collapse in COPD.
T20 2170-2344 Sentence denotes This is associated with increased lung function, suggesting that long-term inhaled steroids modulate airway remodeling thereby potentially preventing airway collapse in COPD.
T21 2345-2423 Sentence denotes Smoking status is not associated with bronchial extracellular matrix proteins.
T21 2345-2423 Sentence denotes Smoking status is not associated with bronchial extracellular matrix proteins.
T22 2424-2443 Sentence denotes TRIAL REGISTRATION:
T22 2424-2443 Sentence denotes TRIAL REGISTRATION:
T23 2444-2475 Sentence denotes ClinicalTrials.gov NCT00158847.
T23 2444-2475 Sentence denotes ClinicalTrials.gov NCT00158847.