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PubMed:23460508 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes Association of polymorphisms in the leptin and leptin receptor genes with inflammatory mediators in patients with osteoporosis.
T1 0-127 Sentence denotes Association of polymorphisms in the leptin and leptin receptor genes with inflammatory mediators in patients with osteoporosis.
T2 128-206 Sentence denotes Bone mass and inflammation are implicated in the pathogenesis of osteoporosis.
T2 128-206 Sentence denotes Bone mass and inflammation are implicated in the pathogenesis of osteoporosis.
T3 207-337 Sentence denotes We hypothesized that leptin and leptin receptor gene might be associated with osteoporosis by activating the inflammatory pathway.
T3 207-337 Sentence denotes We hypothesized that leptin and leptin receptor gene might be associated with osteoporosis by activating the inflammatory pathway.
T4 338-555 Sentence denotes Therefore, we analyzed polymorphisms of the leptin (gene symbol, LEP) and leptin receptor (gene symbol, LEPR) genes and determined their associations with proinflammatory cytokine levels in patients with osteoporosis.
T4 338-555 Sentence denotes Therefore, we analyzed polymorphisms of the leptin (gene symbol, LEP) and leptin receptor (gene symbol, LEPR) genes and determined their associations with proinflammatory cytokine levels in patients with osteoporosis.
T5 556-748 Sentence denotes We assessed polymorphisms in LEP (-2548G > A) and LEPR (Lys109Arg, Gln223Arg, and Lys656Asn) and calculated odds ratios for the genotype and allele distributions between patients and controls.
T5 556-748 Sentence denotes We assessed polymorphisms in LEP (-2548G > A) and LEPR (Lys109Arg, Gln223Arg, and Lys656Asn) and calculated odds ratios for the genotype and allele distributions between patients and controls.
T6 749-992 Sentence denotes Serum leptin, soluble leptin receptor, interleukin (IL)-1, IL-6, IL-7, and tumor necrosis factor (TNF) levels were measured by enzyme-linked immunosorbent assays (ELISA) and were verified by in vitro lymphocyte proliferation assays and ELISAs.
T6 749-992 Sentence denotes Serum leptin, soluble leptin receptor, interleukin (IL)-1, IL-6, IL-7, and tumor necrosis factor (TNF) levels were measured by enzyme-linked immunosorbent assays (ELISA) and were verified by in vitro lymphocyte proliferation assays and ELISAs.
T7 993-1116 Sentence denotes We found a higher frequency of the A allele for LEP at -2548 in patients with osteoporosis compared with the control group.
T7 993-1116 Sentence denotes We found a higher frequency of the A allele for LEP at -2548 in patients with osteoporosis compared with the control group.
T8 1117-1279 Sentence denotes The A allele was associated with differences in serum leptin, soluble leptin receptor, IL-1, IL-6, and TNF levels compared with the wild-type G allele (p < 0.05).
T8 1117-1279 Sentence denotes The A allele was associated with differences in serum leptin, soluble leptin receptor, IL-1, IL-6, and TNF levels compared with the wild-type G allele (p < 0.05).
T9 1280-1509 Sentence denotes The G allele in Lys109Arg and Gln223Arg was associated with increased risk of osteoporosis and with differences in serum leptin, soluble leptin receptor, IL-1, IL-6, and TNF levels compared with the wild-type A allele (p < 0.05).
T9 1280-1509 Sentence denotes The G allele in Lys109Arg and Gln223Arg was associated with increased risk of osteoporosis and with differences in serum leptin, soluble leptin receptor, IL-1, IL-6, and TNF levels compared with the wild-type A allele (p < 0.05).
T10 1510-1582 Sentence denotes The Lys656Asn genotype was not associated with the risk of osteoporosis.
T10 1510-1582 Sentence denotes The Lys656Asn genotype was not associated with the risk of osteoporosis.
T11 1583-1659 Sentence denotes In vitro lymphocyte proliferation assays and ELISAs confirmed these results.
T11 1583-1659 Sentence denotes In vitro lymphocyte proliferation assays and ELISAs confirmed these results.
T12 1660-1809 Sentence denotes Polymorphisms in LEP and LEPR are associated with increased risk of osteoporosis, possibly by increasing the expression of proinflammatory cytokines.
T12 1660-1809 Sentence denotes Polymorphisms in LEP and LEPR are associated with increased risk of osteoporosis, possibly by increasing the expression of proinflammatory cytokines.