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PubMed:23457529 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice.
T1 0-95 Sentence denotes Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice.
T2 96-227 Sentence denotes Squamous cell carcinoma is the second most common form of skin cancer with the incidence expected to double over the next 20 years.
T2 96-227 Sentence denotes Squamous cell carcinoma is the second most common form of skin cancer with the incidence expected to double over the next 20 years.
T3 228-307 Sentence denotes Inflammation is believed to be a critical component in skin cancer progression.
T3 228-307 Sentence denotes Inflammation is believed to be a critical component in skin cancer progression.
T4 308-436 Sentence denotes Therefore, understanding genes involved in the regulation of inflammatory pathways is vital to the design of targeted therapies.
T4 308-436 Sentence denotes Therefore, understanding genes involved in the regulation of inflammatory pathways is vital to the design of targeted therapies.
T5 437-540 Sentence denotes Numerous studies show cyclooxygenases (COXs) play an essential role in inflammation-associated cancers.
T5 437-540 Sentence denotes Numerous studies show cyclooxygenases (COXs) play an essential role in inflammation-associated cancers.
T6 541-621 Sentence denotes Tpl2 (MAP3K8) is a protein kinase in the MAP Kinase signal transduction cascade.
T6 541-621 Sentence denotes Tpl2 (MAP3K8) is a protein kinase in the MAP Kinase signal transduction cascade.
T7 622-810 Sentence denotes Previous research using a two-stage skin carcinogenesis model revealed that Tpl2(-/-) mice have significantly higher tumor incidence and inflammatory response than wild-type (WT) controls.
T7 622-810 Sentence denotes Previous research using a two-stage skin carcinogenesis model revealed that Tpl2(-/-) mice have significantly higher tumor incidence and inflammatory response than wild-type (WT) controls.
T8 811-1049 Sentence denotes The current study investigates whether cyclooxygenase-2 (COX-2) and COX-2- regulated prostaglandins and prostaglandin receptors drive the highly tumorigenic state of Tpl2(-/-) mice by investigating the relationship between Tpl2 and COX-2.
T8 811-1049 Sentence denotes The current study investigates whether cyclooxygenase-2 (COX-2) and COX-2- regulated prostaglandins and prostaglandin receptors drive the highly tumorigenic state of Tpl2(-/-) mice by investigating the relationship between Tpl2 and COX-2.
T9 1050-1191 Sentence denotes Keratinocytes from newborn WT or Tpl2(-/-) mice were treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) for various times over 24 hours.
T9 1050-1191 Sentence denotes Keratinocytes from newborn WT or Tpl2(-/-) mice were treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) for various times over 24 hours.
T10 1192-1308 Sentence denotes Western analysis revealed significant differences in COX-2 and COX-2 dependent prostanoids and prostanoid receptors.
T10 1192-1308 Sentence denotes Western analysis revealed significant differences in COX-2 and COX-2 dependent prostanoids and prostanoid receptors.
T11 1309-1483 Sentence denotes Additionally, in vivo experiments confirmed that COX-2 and COX-2 downstream factors were elevated in TPA-treated Tpl2(-/-) skin, as well as in papillomas from Tpl2(-/-) mice.
T11 1309-1483 Sentence denotes Additionally, in vivo experiments confirmed that COX-2 and COX-2 downstream factors were elevated in TPA-treated Tpl2(-/-) skin, as well as in papillomas from Tpl2(-/-) mice.
T12 1484-1627 Sentence denotes Use of the selective COX-2 inhibitor Celecoxib showed the increased tumorigenesis in the Tpl2(-/-) mice to primarily be mediated through COX-2.
T12 1484-1627 Sentence denotes Use of the selective COX-2 inhibitor Celecoxib showed the increased tumorigenesis in the Tpl2(-/-) mice to primarily be mediated through COX-2.
T13 1628-1771 Sentence denotes These experiments illustrate COX-2 induction in the absence of Tpl2 may be responsible for the increased tumorigenesis found in Tpl2(-/-) mice.
T13 1628-1771 Sentence denotes These experiments illustrate COX-2 induction in the absence of Tpl2 may be responsible for the increased tumorigenesis found in Tpl2(-/-) mice.
T14 1772-1895 Sentence denotes Defining the relationship between Tpl2 and COX-2 may lead to new ways to downregulate COX-2 through the modulation of Tpl2.
T14 1772-1895 Sentence denotes Defining the relationship between Tpl2 and COX-2 may lead to new ways to downregulate COX-2 through the modulation of Tpl2.