| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-83 |
Sentence |
denotes |
Primary, post-primary and non-specific immunoglobulin M responses in HCV infection. |
| T1 |
0-83 |
Sentence |
denotes |
Primary, post-primary and non-specific immunoglobulin M responses in HCV infection. |
| T2 |
84-190 |
Sentence |
denotes |
Delayed and variable antibody responses to HCV make it difficult to diagnose acute HCV infection reliably. |
| T2 |
84-190 |
Sentence |
denotes |
Delayed and variable antibody responses to HCV make it difficult to diagnose acute HCV infection reliably. |
| T3 |
191-280 |
Sentence |
denotes |
Immunoglobulin (Ig)M and IgG anti-HCV may be observed simultaneously as disease persists. |
| T3 |
191-280 |
Sentence |
denotes |
Immunoglobulin (Ig)M and IgG anti-HCV may be observed simultaneously as disease persists. |
| T4 |
281-410 |
Sentence |
denotes |
IgM plays a key role in mixed cryoglobulinemia (MC), an immune complex disease strongly associated with persistent HCV infection. |
| T4 |
281-410 |
Sentence |
denotes |
IgM plays a key role in mixed cryoglobulinemia (MC), an immune complex disease strongly associated with persistent HCV infection. |
| T5 |
411-609 |
Sentence |
denotes |
In MC, clonal or oligoclonal IgM rheumatoid factors facilitate the deposition of immune complexes in small blood vessels and tissue, leading to inflammation, complement activation and tissue damage. |
| T5 |
411-609 |
Sentence |
denotes |
In MC, clonal or oligoclonal IgM rheumatoid factors facilitate the deposition of immune complexes in small blood vessels and tissue, leading to inflammation, complement activation and tissue damage. |
| T6 |
610-727 |
Sentence |
denotes |
Clonally expanded IgM(+)κ(+) B-cells expressing rheumatoid factor-like IgM are abundant in many HCV patients with MC. |
| T6 |
610-727 |
Sentence |
denotes |
Clonally expanded IgM(+)κ(+) B-cells expressing rheumatoid factor-like IgM are abundant in many HCV patients with MC. |
| T7 |
728-1000 |
Sentence |
denotes |
The observation that identical or similar IgM antibodies are expressed in different patients' clonally expanded B-cells supports the hypothesis that MC is driven by antigen-specific B-cell activation, rather than polyclonal B-cell activation or HCV replication in B-cells. |
| T7 |
728-1000 |
Sentence |
denotes |
The observation that identical or similar IgM antibodies are expressed in different patients' clonally expanded B-cells supports the hypothesis that MC is driven by antigen-specific B-cell activation, rather than polyclonal B-cell activation or HCV replication in B-cells. |
| T8 |
1001-1082 |
Sentence |
denotes |
More study is required to identify the antigens that drive the development of MC. |
| T8 |
1001-1082 |
Sentence |
denotes |
More study is required to identify the antigens that drive the development of MC. |