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PubMed:23280345 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Synergistic effects of interleukin-1β and interleukin-17A antibodies on collagen-induced arthritis mouse model.
T1 0-111 Sentence denotes Synergistic effects of interleukin-1β and interleukin-17A antibodies on collagen-induced arthritis mouse model.
T2 112-260 Sentence denotes Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that mainly causes the synovial joint inflammation and cartilage destruction.
T2 112-260 Sentence denotes Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that mainly causes the synovial joint inflammation and cartilage destruction.
T3 261-391 Sentence denotes Both interleukin-1β (IL-1β) and Interleukin-17 (IL-17) are important proinflammatory cytokines involved in the pathogenesis of RA.
T3 261-391 Sentence denotes Both interleukin-1β (IL-1β) and Interleukin-17 (IL-17) are important proinflammatory cytokines involved in the pathogenesis of RA.
T4 392-572 Sentence denotes We investigated whether combination therapy with IL-1β and IL-17A antibodies would generate the potential for synergistic effects on a collagen-induced arthritis (CIA) mouse model.
T4 392-572 Sentence denotes We investigated whether combination therapy with IL-1β and IL-17A antibodies would generate the potential for synergistic effects on a collagen-induced arthritis (CIA) mouse model.
T5 573-689 Sentence denotes Mice with CIA were subcutaneously injected with humanized IL-1β antibody, IL-17A antibody, or combination treatment.
T5 573-689 Sentence denotes Mice with CIA were subcutaneously injected with humanized IL-1β antibody, IL-17A antibody, or combination treatment.
T6 690-877 Sentence denotes The effects of treatment were determined by arthritis severity score, histological damage and bone destruction, autoreactive humoral and cellular immune responses and cytokine production.
T6 690-877 Sentence denotes The effects of treatment were determined by arthritis severity score, histological damage and bone destruction, autoreactive humoral and cellular immune responses and cytokine production.
T7 878-1016 Sentence denotes Treatment with IL-1β antibody or IL-17A antibody alone resulted in beneficial effects on clinical and histological parameters of CIA mice.
T7 878-1016 Sentence denotes Treatment with IL-1β antibody or IL-17A antibody alone resulted in beneficial effects on clinical and histological parameters of CIA mice.
T8 1017-1372 Sentence denotes Compared with the single antibody treatments, the combination therapy resulted in a more significant effect in alleviating the severity of arthritis by preventing bone damage and cartilage destruction, reducing humoral and cellular immune responses, and down-regulating the expression of IL-1β, IL-6, IL-17A, IFN-γ, RANKL and MMP-3 in inflammatory tissue.
T8 1017-1372 Sentence denotes Compared with the single antibody treatments, the combination therapy resulted in a more significant effect in alleviating the severity of arthritis by preventing bone damage and cartilage destruction, reducing humoral and cellular immune responses, and down-regulating the expression of IL-1β, IL-6, IL-17A, IFN-γ, RANKL and MMP-3 in inflammatory tissue.
T9 1373-1591 Sentence denotes In conclusion, combination treatment with humanized IL-1β and IL-17A antibodies demonstrates synergistic beneficial effects for preventing joint inflammation and cartilage destruction and bone damage in CIA mice model.
T9 1373-1591 Sentence denotes In conclusion, combination treatment with humanized IL-1β and IL-17A antibodies demonstrates synergistic beneficial effects for preventing joint inflammation and cartilage destruction and bone damage in CIA mice model.
T10 1592-1734 Sentence denotes These studies also provide evidence that combination with IL-1β and IL-17A antibodies may lead to a new combinatorial therapy for RA patients.
T10 1592-1734 Sentence denotes These studies also provide evidence that combination with IL-1β and IL-17A antibodies may lead to a new combinatorial therapy for RA patients.