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PubMed:23267857 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-81 Sentence denotes CYP2C19*17 gain-of-function polymorphism is associated with peptic ulcer disease.
T1 0-81 Sentence denotes CYP2C19*17 gain-of-function polymorphism is associated with peptic ulcer disease.
T2 82-331 Sentence denotes Single-nucleotide polymorphisms (SNPs) in the CYP2C gene cluster have been extensively investigated as predisposing factors for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer disease (PUD) or upper gastrointestinal bleeding (UGIB).
T2 82-331 Sentence denotes Single-nucleotide polymorphisms (SNPs) in the CYP2C gene cluster have been extensively investigated as predisposing factors for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer disease (PUD) or upper gastrointestinal bleeding (UGIB).
T3 332-460 Sentence denotes However, results have been inconclusive owing to different study designs, limited genotyping strategies, and small sample sizes.
T3 332-460 Sentence denotes However, results have been inconclusive owing to different study designs, limited genotyping strategies, and small sample sizes.
T4 461-695 Sentence denotes We investigated whether eight functional SNPs in the CYP2C family of genes--CYP2C8*3 (rs11572080 and rs10509681), CYP2C8*4, CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, and CYP2C19*17--are associated with PUD in 1,239 Caucasian patients.
T4 461-695 Sentence denotes We investigated whether eight functional SNPs in the CYP2C family of genes--CYP2C8*3 (rs11572080 and rs10509681), CYP2C8*4, CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, and CYP2C19*17--are associated with PUD in 1,239 Caucasian patients.
T5 696-804 Sentence denotes Logistic regression analysis showed that only CYP2C19*17 was associated with PUD (odds ratio additive model:
T5 696-804 Sentence denotes Logistic regression analysis showed that only CYP2C19*17 was associated with PUD (odds ratio additive model:
T6 805-949 Sentence denotes 1.47 (95% confidence interval (CI) 1.12 to 1.92); P = 0.005; R(2) 16%), but not UGIB, independent of NSAID use or Helicobacter pylori infection.
T6 805-949 Sentence denotes 1.47 (95% confidence interval (CI) 1.12 to 1.92); P = 0.005; R(2) 16%), but not UGIB, independent of NSAID use or Helicobacter pylori infection.
T7 950-1085 Sentence denotes PUD distribution varied (P = 0.024) according to CYP2C19*17 genotype: *1/*1, 490 (64.3%); *1/*17, 304 (71.7%); and *17/*17, 31 (73.8%).
T7 950-1085 Sentence denotes PUD distribution varied (P = 0.024) according to CYP2C19*17 genotype: *1/*1, 490 (64.3%); *1/*17, 304 (71.7%); and *17/*17, 31 (73.8%).
T8 1086-1179 Sentence denotes CYP2C19*17, a gain-of-function polymorphism, is associated with PUD irrespective of etiology.
T8 1086-1179 Sentence denotes CYP2C19*17, a gain-of-function polymorphism, is associated with PUD irrespective of etiology.