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PubMed:21784820 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Effect of phosphate binders on serum inflammatory profile, soluble CD14, and endotoxin levels in hemodialysis patients.
T1 0-119 Sentence denotes Effect of phosphate binders on serum inflammatory profile, soluble CD14, and endotoxin levels in hemodialysis patients.
T2 120-146 Sentence denotes BACKGROUND AND OBJECTIVES:
T2 120-146 Sentence denotes BACKGROUND AND OBJECTIVES:
T3 147-237 Sentence denotes Hyperphosphatemia and subclinical endotoxemia are important sources of inflammation in HD.
T3 147-237 Sentence denotes Hyperphosphatemia and subclinical endotoxemia are important sources of inflammation in HD.
T4 238-383 Sentence denotes Proinflammatory cytokines are strong correlates of soluble CD14 (sCD14) concentrations, an independent predictor of mortality in this population.
T4 238-383 Sentence denotes Proinflammatory cytokines are strong correlates of soluble CD14 (sCD14) concentrations, an independent predictor of mortality in this population.
T5 384-545 Sentence denotes We evaluated the effects of calcium acetate and sevelamer hydrochloride on serum inflammatory profile, endotoxin concentrations, and sCD14 levels in HD patients.
T5 384-545 Sentence denotes We evaluated the effects of calcium acetate and sevelamer hydrochloride on serum inflammatory profile, endotoxin concentrations, and sCD14 levels in HD patients.
T6 546-592 Sentence denotes DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:
T6 546-592 Sentence denotes DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:
T7 593-652 Sentence denotes Prospective, randomized, open-label, parallel design trial.
T7 593-652 Sentence denotes Prospective, randomized, open-label, parallel design trial.
T8 653-756 Sentence denotes Fifty-nine stable HD patients, 30 receiving sevelamer, and 29 receiving calcium acetate were evaluated.
T8 653-756 Sentence denotes Fifty-nine stable HD patients, 30 receiving sevelamer, and 29 receiving calcium acetate were evaluated.
T9 757-993 Sentence denotes Serum levels of inflammatory parameters (high-sensitivity C-reactive protein [hs-CRP], TNF-α, interleukin (IL)-1, -6, -10, and -18), as well as endotoxin and sCD14 concentrations, were measured at baseline and after 3 months of therapy.
T9 757-993 Sentence denotes Serum levels of inflammatory parameters (high-sensitivity C-reactive protein [hs-CRP], TNF-α, interleukin (IL)-1, -6, -10, and -18), as well as endotoxin and sCD14 concentrations, were measured at baseline and after 3 months of therapy.
T10 994-1002 Sentence denotes RESULTS:
T10 994-1002 Sentence denotes RESULTS:
T11 1003-1203 Sentence denotes Serum IL-6 increased in patients receiving calcium acetate, whereas hs-CRP and IL-6 significantly decreased in subjects treated with sevelamer, with IL-10 experiencing a trend to increase (P = 0.052).
T11 1003-1203 Sentence denotes Serum IL-6 increased in patients receiving calcium acetate, whereas hs-CRP and IL-6 significantly decreased in subjects treated with sevelamer, with IL-10 experiencing a trend to increase (P = 0.052).
T12 1204-1289 Sentence denotes Serum endotoxin and sCD14 levels did not change after treatment with calcium acetate.
T12 1204-1289 Sentence denotes Serum endotoxin and sCD14 levels did not change after treatment with calcium acetate.
T13 1290-1403 Sentence denotes However, these parameters decreased by 22.6% and 15.2%, respectively (P < 0.01), in patients receiving sevelamer.
T13 1290-1403 Sentence denotes However, these parameters decreased by 22.6% and 15.2%, respectively (P < 0.01), in patients receiving sevelamer.
T14 1404-1687 Sentence denotes Multiple regression analysis showed that variation in serum endotoxin concentrations was the strongest factor associated with IL-6 change, whereas the only variables independently associated with changes in sCD14 levels were the variations in serum IL-6 and endotoxin concentrations.
T14 1404-1687 Sentence denotes Multiple regression analysis showed that variation in serum endotoxin concentrations was the strongest factor associated with IL-6 change, whereas the only variables independently associated with changes in sCD14 levels were the variations in serum IL-6 and endotoxin concentrations.
T15 1688-1700 Sentence denotes CONCLUSIONS:
T15 1688-1700 Sentence denotes CONCLUSIONS:
T16 1701-1895 Sentence denotes Administration of the noncalcium phosphate binder sevelamer to maintenance HD patients is associated with a significant decrease in hs-CRP, IL-6, serum endotoxin levels and sCD14 concentrations.
T16 1701-1895 Sentence denotes Administration of the noncalcium phosphate binder sevelamer to maintenance HD patients is associated with a significant decrease in hs-CRP, IL-6, serum endotoxin levels and sCD14 concentrations.