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PubMed:21768350 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-136 Sentence denotes Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins.
T1 0-136 Sentence denotes Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins.
T2 137-291 Sentence denotes The serine protease autotransporters of Enterobacteriaceae (SPATEs) are secreted by pathogenic Gram-negative bacteria through the autotransporter pathway.
T2 137-291 Sentence denotes The serine protease autotransporters of Enterobacteriaceae (SPATEs) are secreted by pathogenic Gram-negative bacteria through the autotransporter pathway.
T3 292-397 Sentence denotes We previously classified SPATE proteins into two classes: cytotoxic (class 1) and noncytotoxic (class 2).
T3 292-397 Sentence denotes We previously classified SPATE proteins into two classes: cytotoxic (class 1) and noncytotoxic (class 2).
T4 398-601 Sentence denotes Here, we show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a, uropathogenic and enteroaggregative Escherichia coli strains, targets a broad range of human leukocyte adhesion proteins.
T4 398-601 Sentence denotes Here, we show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a, uropathogenic and enteroaggregative Escherichia coli strains, targets a broad range of human leukocyte adhesion proteins.
T5 602-883 Sentence denotes Substrate specificity was restricted to glycoproteins rich in O-linked glycans, including CD43, CD44, CD45, CD93, CD162 (PSGL-1; P-selectin glycoprotein ligand 1), and the surface-attached chemokine fractalkine, all implicated in leukocyte trafficking, migration, and inflammation.
T5 602-883 Sentence denotes Substrate specificity was restricted to glycoproteins rich in O-linked glycans, including CD43, CD44, CD45, CD93, CD162 (PSGL-1; P-selectin glycoprotein ligand 1), and the surface-attached chemokine fractalkine, all implicated in leukocyte trafficking, migration, and inflammation.
T6 884-1030 Sentence denotes N-terminal sequencing of proteolytic products revealed Pic (protease involved in colonization) cleavage sites to occur before Thr or Ser residues.
T6 884-1030 Sentence denotes N-terminal sequencing of proteolytic products revealed Pic (protease involved in colonization) cleavage sites to occur before Thr or Ser residues.
T7 1031-1141 Sentence denotes The purified carbohydrate sLewis-X implied in inflammation and malignancy inhibited cleavage of PSGL-1 by Pic.
T7 1031-1141 Sentence denotes The purified carbohydrate sLewis-X implied in inflammation and malignancy inhibited cleavage of PSGL-1 by Pic.
T8 1142-1330 Sentence denotes Exposure of human leukocytes to purified Pic resulted in polymorphonuclear cell activation, but impaired chemotaxis and transmigration; Pic-treated T cells underwent programmed cell death.
T8 1142-1330 Sentence denotes Exposure of human leukocytes to purified Pic resulted in polymorphonuclear cell activation, but impaired chemotaxis and transmigration; Pic-treated T cells underwent programmed cell death.
T9 1331-1492 Sentence denotes We also show that the Pic-related protease Tsh/Hbp, implicated in extraintestinal infections, exhibited a spectrum of substrates similar to those cleaved by Pic.
T9 1331-1492 Sentence denotes We also show that the Pic-related protease Tsh/Hbp, implicated in extraintestinal infections, exhibited a spectrum of substrates similar to those cleaved by Pic.
T10 1493-1613 Sentence denotes In the guinea pig keratoconjunctivitis model, a Shigella pic mutant induced greater inflammation than its parent strain.
T10 1493-1613 Sentence denotes In the guinea pig keratoconjunctivitis model, a Shigella pic mutant induced greater inflammation than its parent strain.
T11 1614-1712 Sentence denotes We suggest that the class-2 SPATEs represent unique immune-modulating bacterial virulence factors.
T11 1614-1712 Sentence denotes We suggest that the class-2 SPATEs represent unique immune-modulating bacterial virulence factors.