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PubMed:21760535 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes Prominent microglial activation in the early proinflammatory immune response in naturally occurring canine spinal cord injury.
T1 0-126 Sentence denotes Prominent microglial activation in the early proinflammatory immune response in naturally occurring canine spinal cord injury.
T2 127-256 Sentence denotes Better understanding of the pathogenesis of spinal cord injury (SCI) is needed for the development of new therapeutic strategies.
T2 127-256 Sentence denotes Better understanding of the pathogenesis of spinal cord injury (SCI) is needed for the development of new therapeutic strategies.
T3 257-428 Sentence denotes Spinal cord injury has been investigated in various rodent models, but extrapolation to humans requires the use of a large animal model that more closely mimics human SCI.
T3 257-428 Sentence denotes Spinal cord injury has been investigated in various rodent models, but extrapolation to humans requires the use of a large animal model that more closely mimics human SCI.
T4 429-541 Sentence denotes Dogs frequently develop spontaneous SCI with features that bear a striking resemblance to the human counterpart.
T4 429-541 Sentence denotes Dogs frequently develop spontaneous SCI with features that bear a striking resemblance to the human counterpart.
T5 542-735 Sentence denotes We investigated the temporal course of the immune response during naturally occurring canine SCI and in organotypic canine spinal cord slice cultures that are devoid of peripheral immune cells.
T5 542-735 Sentence denotes We investigated the temporal course of the immune response during naturally occurring canine SCI and in organotypic canine spinal cord slice cultures that are devoid of peripheral immune cells.
T6 736-966 Sentence denotes By immunohistochemistry, the inflammatory response in subacute canine SCI was largely restricted to resident immune cells as demonstrated by activation of major histocompatibility complex class II-expressing microglia/macrophages.
T6 736-966 Sentence denotes By immunohistochemistry, the inflammatory response in subacute canine SCI was largely restricted to resident immune cells as demonstrated by activation of major histocompatibility complex class II-expressing microglia/macrophages.
T7 967-1204 Sentence denotes By quantitative polymerase chain reaction, there was parallel upregulation of proinflammatory cytokine gene expression (i.e. of interleukin 6 [IL-6] and IL-8 with a trend toward upregulation of tumor necrosis factor) in acute canine SCI.
T7 967-1204 Sentence denotes By quantitative polymerase chain reaction, there was parallel upregulation of proinflammatory cytokine gene expression (i.e. of interleukin 6 [IL-6] and IL-8 with a trend toward upregulation of tumor necrosis factor) in acute canine SCI.
T8 1205-1336 Sentence denotes Expression of neuroprotective cytokines (e.g. IL-10) remained unchanged, and transforming growth factor β upregulation was delayed.
T8 1205-1336 Sentence denotes Expression of neuroprotective cytokines (e.g. IL-10) remained unchanged, and transforming growth factor β upregulation was delayed.
T9 1337-1626 Sentence denotes In organotypic spinal cord slices, there was similar activation of major histocompatibility complex class II-positive microglia and prolonged upregulation of inflammatory cytokines, indicating that resident rather than infiltrating cells play major roles in the postinjury immune response.
T9 1337-1626 Sentence denotes In organotypic spinal cord slices, there was similar activation of major histocompatibility complex class II-positive microglia and prolonged upregulation of inflammatory cytokines, indicating that resident rather than infiltrating cells play major roles in the postinjury immune response.
T10 1627-1768 Sentence denotes Thus, canine SCI represents a bridge between rodent models and human SCI that may be relevant for clinical and preclinical treatment studies.
T10 1627-1768 Sentence denotes Thus, canine SCI represents a bridge between rodent models and human SCI that may be relevant for clinical and preclinical treatment studies.