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PubMed:21497535 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.
T1 0-111 Sentence denotes Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.
T2 112-123 Sentence denotes OBJECTIVES:
T2 112-123 Sentence denotes OBJECTIVES:
T3 124-236 Sentence denotes The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA).
T3 124-236 Sentence denotes The imbalance between proinflammatory and anti-inflammatory cytokines is a feature of rheumatoid arthritis (RA).
T4 237-328 Sentence denotes The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting.
T4 237-328 Sentence denotes The role of interleukin-4 (IL-4) and its receptor in the pathogenesis of RA is conflicting.
T5 329-433 Sentence denotes We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.
T5 329-433 Sentence denotes We aim to investigate the role of polymorphisms in the IL-4Rα gene in susceptibility and severity of RA.
T6 434-442 Sentence denotes METHODS:
T6 434-442 Sentence denotes METHODS:
T7 443-527 Sentence denotes One hundred and seventy-two RA patients and 172 controls were enrolled in the study.
T7 443-527 Sentence denotes One hundred and seventy-two RA patients and 172 controls were enrolled in the study.
T8 528-691 Sentence denotes Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).
T8 528-691 Sentence denotes Genotyping of IL-4Rα I50V (rs1805010) and IL-4Rα Q576R (rs1801275) was determined by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP).
T9 692-795 Sentence denotes RESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR:
T9 692-795 Sentence denotes RESULTS: IL-4Rα I50V genotype was significantly more frequent in patients with RA than in controls (OR:
T10 796-809 Sentence denotes 1.97, 95% CI:
T10 796-809 Sentence denotes 1.97, 95% CI:
T11 810-819 Sentence denotes 1-3.7, P:
T11 810-819 Sentence denotes 1-3.7, P:
T12 820-827 Sentence denotes 0.035).
T12 820-827 Sentence denotes 0.035).
T13 828-926 Sentence denotes Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR:
T13 828-926 Sentence denotes Subjects with IL-4Rα V50V genotype were significantly more likely to have erosive arthropathy (OR:
T14 927-939 Sentence denotes 2.6, 95% CI:
T14 927-939 Sentence denotes 2.6, 95% CI:
T15 940-951 Sentence denotes 1.1-6.1, P:
T15 940-951 Sentence denotes 1.1-6.1, P:
T16 952-958 Sentence denotes 0.02).
T16 952-958 Sentence denotes 0.02).
T17 959-1121 Sentence denotes The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR:
T17 959-1121 Sentence denotes The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR:
T18 1122-1134 Sentence denotes 2.7, 95% CI:
T18 1122-1134 Sentence denotes 2.7, 95% CI:
T19 1135-1144 Sentence denotes 1-7.7, P:
T19 1135-1144 Sentence denotes 1-7.7, P:
T20 1145-1151 Sentence denotes 0.04).
T20 1145-1151 Sentence denotes 0.04).
T21 1152-1279 Sentence denotes CONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA.
T21 1152-1279 Sentence denotes CONCLUSION: IL-4Rα polymorphisms were associated with susceptibility to RA and may be helpful in early detection of erosive RA.