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PubMed:21070631 JSONTXT 28 Projects

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Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project.
T1 0-125 Sentence denotes The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project.
T2 126-137 Sentence denotes BACKGROUND:
T2 126-137 Sentence denotes BACKGROUND:
T3 138-243 Sentence denotes The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD).
T3 138-243 Sentence denotes The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD).
T4 244-327 Sentence denotes Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline.
T4 244-327 Sentence denotes Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline.
T5 328-521 Sentence denotes Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and polymorphisms of the pro-inflammatory cytokine genes, IL1A and IL6, contributing to the risk of AD.
T5 328-521 Sentence denotes Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and polymorphisms of the pro-inflammatory cytokine genes, IL1A and IL6, contributing to the risk of AD.
T6 522-698 Sentence denotes We therefore examined the associations with AD of the DBH -1021T allele and of the above interactions in the Epistasis Project, with 1757 cases of AD and 6294 elderly controls.
T6 522-698 Sentence denotes We therefore examined the associations with AD of the DBH -1021T allele and of the above interactions in the Epistasis Project, with 1757 cases of AD and 6294 elderly controls.
T7 699-707 Sentence denotes METHODS:
T7 699-707 Sentence denotes METHODS:
T8 708-804 Sentence denotes We genotyped eight single nucleotide polymorphisms (SNPs) in the three genes, DBH, IL1A and IL6.
T8 708-804 Sentence denotes We genotyped eight single nucleotide polymorphisms (SNPs) in the three genes, DBH, IL1A and IL6.
T9 805-927 Sentence denotes We used logistic regression models and synergy factor analysis to examine potential interactions and associations with AD.
T9 805-927 Sentence denotes We used logistic regression models and synergy factor analysis to examine potential interactions and associations with AD.
T10 928-936 Sentence denotes RESULTS:
T10 928-936 Sentence denotes RESULTS:
T11 937-1051 Sentence denotes We found that the presence of the -1021T allele was associated with AD: odds ratio = 1.2 (95% confidence interval:
T11 937-1051 Sentence denotes We found that the presence of the -1021T allele was associated with AD: odds ratio = 1.2 (95% confidence interval:
T12 1052-1073 Sentence denotes 1.06-1.4, p = 0.005).
T12 1052-1073 Sentence denotes 1.06-1.4, p = 0.005).
T13 1074-1171 Sentence denotes This association was nearly restricted to men < 75 years old: odds ratio = 2.2 (1.4-3.3, 0.0004).
T13 1074-1171 Sentence denotes This association was nearly restricted to men < 75 years old: odds ratio = 2.2 (1.4-3.3, 0.0004).
T14 1172-1319 Sentence denotes We also found an interaction between the presence of DBH -1021T and the -889TT genotype (rs1800587) of IL1A: synergy factor = 1.9 (1.2-3.1, 0.005).
T14 1172-1319 Sentence denotes We also found an interaction between the presence of DBH -1021T and the -889TT genotype (rs1800587) of IL1A: synergy factor = 1.9 (1.2-3.1, 0.005).
T15 1320-1391 Sentence denotes All these results were consistent between North Europe and North Spain.
T15 1320-1391 Sentence denotes All these results were consistent between North Europe and North Spain.
T16 1392-1404 Sentence denotes CONCLUSIONS:
T16 1392-1404 Sentence denotes CONCLUSIONS:
T17 1405-1540 Sentence denotes Extensive, previous evidence (reviewed here) indicates an important role for noradrenaline in the control of inflammation in the brain.
T17 1405-1540 Sentence denotes Extensive, previous evidence (reviewed here) indicates an important role for noradrenaline in the control of inflammation in the brain.
T18 1541-1688 Sentence denotes Thus, the -1021T allele with presumed low activity may be associated with misregulation of inflammation, which could contribute to the onset of AD.
T18 1541-1688 Sentence denotes Thus, the -1021T allele with presumed low activity may be associated with misregulation of inflammation, which could contribute to the onset of AD.
T19 1689-1787 Sentence denotes We suggest that such misregulation is the predominant mechanism of the association we report here.
T19 1689-1787 Sentence denotes We suggest that such misregulation is the predominant mechanism of the association we report here.